Original paper
Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers
Abstract
Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop highly selective small molecule inhibitors of HDAC2, a chromatin modifying histone deacetylase implicated in memory formation and synaptic plasticity. Novel ortho-aminoanilide inhibitors were designed and evaluated for their ability to selectively inhibit HDAC2 versus the other Class I...
Paper Details
Title
Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers
Published Date
Jan 1, 2015
Journal
Volume
6
Issue
1
Pages
804 - 815
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Notes
History