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#1Jiacheng Lin (University of Cambridge)H-Index: 5
#2Chiara Figazzolo (University of Cambridge)
Last. Michele Vendruscolo (University of Cambridge)H-Index: 100
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The expansion of structural databases and the increase in computing power are enabling approaches for antibody discovery based on computational design. It has already been shown that it is possible to use this approach to generate antibodies for specific epitopes on challenging targets. Here we describe an application of this procedure for antibody maturation through the computational design of mutational variants of increased potency. We illustrate this procedure in the case of a single-domain ...
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#1Mahdi Hesari (UWO: University of Western Ontario)H-Index: 19
#2Hui Ma (NU: Nanjing University)
Last. Zhifeng Ding (UWO: University of Western Ontario)H-Index: 40
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Herein, we report for the first time single Au38 nanocluster reaction events of highly efficient electrochemiluminescence (ECL) with tri-n-propylamine radicals as a reductive co-reactant at the surface of an ultramicroelectrode (UME). The statistical analyses of individual reactions confirm stochastic single ones influenced by the applied potential.
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#1Jinbo Zhu (University of Cambridge)H-Index: 24
#2Zhiqiang Yan (CAS: Chinese Academy of Sciences)H-Index: 9
Last. Ulrich F. Keyser (University of Cambridge)H-Index: 56
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Since the discovery of the G-quadruplex (G4) structure in telomeres in 1980s, studies have established the role it plays in various biological processes. Here we report binding between DNA G4 and a self-assembled tetrahedral metal-organic cage 1 and consequent formation of aggregates, whereby the cage protects the DNA G4 from cleavage by S1 nuclease. We monitor DNA–cage interaction using fluorescence spectroscopy, firstly by quenching of a fluorescent label appended to the 5′ end of G4. Secondly...
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#1Ying Qin (NKU: Nankai University)
#2Lianghui Li (NKU: Nankai University)
Last. Dongbing Zhao (NKU: Nankai University)H-Index: 33
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Silicon-based cross-coupling has been recognized as one of the most reliable alternatives for constructing carbon–carbon bonds. However, the employment of such reaction as an efficient ring expansion strategy for silacycle synthesis is comparatively little known. Herein, we develop the first intermolecular silacyclization strategy involving Pd-catalyzed silicon-based C(sp2)–C(sp3) cross-coupling. This method allows the modular assembly of a vast array of structurally novel and interesting sila-b...
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#1Noriyoshi Oe (UTokyo: University of Tokyo)
#2Nobuhiko Hosono (UTokyo: University of Tokyo)H-Index: 18
Last. Takashi Uemura (UTokyo: University of Tokyo)H-Index: 40
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Adsorption of polymers from the solution phase has been extensively studied to cope with many demands not only for separation technologies, but also for the development of coatings, adhesives, and biocompatible materials. Most studies hitherto focus on adsorption on flat surfaces and mesoporous adsorbents with open frameworks, plausibly because of the preconceived notion that it is unlikely for polymers to enter a pore with a diameter that is smaller than the gyration diameter of the polymer in ...
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#1Rémi Martinent (University of Geneva)H-Index: 2
#2Salman Tawffik (University of Geneva)
Last. Stefan Matile (University of Geneva)H-Index: 78
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The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated uptake is reported. This is important because most orthodox systems, including polycationic cell-penetrating peptides, fail to deliver efficiently into deep tissue. The grand principles of supramolecular chemistry, that is the pH dependence of dynamic covalent disulfide exchange with known thiols on the transferrin receptor, are proposed to account for transcytosis into deep tissue, while the known but e...
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#1Sourav Dey (IITB: Indian Institute of Technology Bombay)H-Index: 7
#2Gopalan Rajaraman (IITB: Indian Institute of Technology Bombay)H-Index: 55
While the blocking barrier (Ueff) and blocking temperature (TB) for “Dysprocenium” SIMs have been increased beyond liquid N2 temperature, device fabrication of these molecules remains a challenge as low-coordinate Ln3+ complexes are very unstable. Encapsulating the lanthanide ion inside a cage such as a fullerene (called endohedral metallofullerene or EMF) opens up a new avenue leading to several Ln@EMF SMMs. The ab initio CASSCF calculations play a pivotal role in identifying target metal ions ...
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#1Mengyi Yang (THU: Tsinghua University)H-Index: 2
#2Ruirui Sun (THU: Tsinghua University)H-Index: 4
Last. Chunlai Chen (THU: Tsinghua University)H-Index: 18
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RNA-guided Streptococcus pyogenes Cas9 (SpCas9) is a sequence-specific DNA endonuclease that works as one of the most powerful genetic editing tools. However, how Cas9 locates its target among huge amounts of dsDNAs remains elusive. Here, combining biochemical and single-molecule fluorescence assays, we revealed that Cas9 uses both three-dimensional and one-dimensional diffusion to find its target with high efficiency. We further observed surprising apparent asymmetric target search regions flan...
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#1Min Sun Kang (NTU: Nanyang Technological University)
#2Theresa Wai See Kong (NTU: Nanyang Technological University)
Last. Teck-Peng Loh (NTU: Nanyang Technological University)H-Index: 61
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Many fields in chemical biology and synthetic biology require effective bioconjugation methods to achieve their desired functions and activities. Among such biomolecule conjugates, antibody–drug conjugates (ADCs) need a linker that provides a stable linkage between cytotoxic drugs and antibodies, whilst conjugating in a biologically benign, fast and selective fashion. This review focuses on how the development of novel organic synthesis can solve the problems of traditional linker technology. Th...
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#1Amreen K. Bains (IISc: Indian Institute of Science)H-Index: 5
#2Abhishek Kundu (IISc: Indian Institute of Science)H-Index: 3
Last. Debashis Adhikari (IISc: Indian Institute of Science)H-Index: 19
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A well-defined, bench-stable nickel catalyst is presented here, that can facilitate double alkylation of a methyl ketone to realize a wide variety of cycloalkanes. The performance of the catalyst depends on the ligand redox process comprising an azo-hydrazo couple. The source of the bis electrophile in this double alkylation is a 1,n-diol, so that (n+1)-membered cycloalkanes can be furnished in a stereoselective manner. The reaction follows a cascade of dehydrogenation/hydrogenation reactions an...
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