False-positive uptake on 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) in oncological imaging

Published on Apr 1, 2011in Clinical Radiology2.118
· DOI :10.1016/J.CRAD.2010.12.004
A. D. Culverwell2
Estimated H-index: 2
(Leeds Teaching Hospitals NHS Trust),
Andrew Scarsbrook29
Estimated H-index: 29
(Leeds Teaching Hospitals NHS Trust),
Fahmid U. Chowdhury18
Estimated H-index: 18
(Leeds Teaching Hospitals NHS Trust)
With the increasing utilization of integrated positron-emission tomography/computed tomography (PET/CT) using the glucose analogue 2-[18F]-fluoro-2-deoxy- d- glucose (FDG) in oncological imaging, it is important for radiologists and nuclear medicine physicians to be aware that FDG uptake is not specific for malignancy, as many different physiological variants and benign pathological conditions can also exhibit increased glucose metabolism. Such false-positive FDG uptake often arises outside the area of primary interest and may mimic malignant disease, thereby confounding accurate interpretation of PET/CT studies. With the use of illustrative clinical cases, this article will provide a systematic overview of potential interpretative pitfalls and illustrate how such unexpected findings can be appropriately evaluated.
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