Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors
Abstract
Skp1 is an essential adaptor protein of the Skp1-Cul1-F-box protein complex and is able to stabilize the conformation of some ubiquitin E3 ligases. However, the role Skp1 plays during tumorigenesis remains unclear and Skp1-targeting agent is lacking. Here we showed that Skp1 was overexpressed in 36/64 (56.3%) of non-small cell lung cancers, and elevated Skp1 was associated with poor prognosis. By structure-based high-throughput virtual...
Paper Details
Title
Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors
Published Date
Oct 12, 2015
Journal
Volume
6
Issue
33
Pages
34953 - 34967
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