The temporal evolution of antidrug antibodies in patients with inflammatory bowel disease treated with infliximab

Objective

To characterise the temporal evolution of antibodies to infliximab (ATI).

Design

Prospective observational study of infliximab-treated patients with inflammatory bowel disease between 2009 and 2012.

Interventions

Trough levels of infliximab and ATI were measured before each infusion by anti-λ ELISA. Patients were monitored for disease activity by clinical activity indexes and for dose-intensification or...