Complication of chronic eosinophilic pneumonia in an elderly patient with Sjögren syndrome.

Published on Jan 1, 2015in Acta Medica Okayama0.642
· DOI :10.18926/AMO/53342
Koichi Waseda9
Estimated H-index: 9
,
Hideharu Hagiya7
Estimated H-index: 7
+ 9 AuthorsFumio Otsuka35
Estimated H-index: 35
Sources
Abstract
An 81-year-old Japanese male with primary Sjogren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients.
References21
Newest
#1Yuehui Liu (NCU: Nanchang University)H-Index: 1
#2Xinhua Zhu (NCU: Nanchang University)H-Index: 1
Last. Hao Zhang (NCU: Nanchang University)H-Index: 1
view all 3 authors...
The present study aimed to use RNA interference (RNAi) to silence chemokine receptor 3 (CCR3) and observe the effects on eosinophils (EOS) in mice with allergic rhinitis (AR). CCR3 small interfering RNA (siRNA) lentiviral vectors were transduced into purified EOS cells cultured in vitro. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot analyses were also used to detect the efficiency of silencing, and flow cytometry was used to detect the EOS apoptosis rates. Experimenta...
3 CitationsSource
#1Katsutoshi Ando (Juntendo University)H-Index: 11
#2Tamao NakashitaH-Index: 6
Last. Shinji MotojimaH-Index: 5
view all 5 authors...
Increased levels of serum pro-fibrotic cytokines have been reported in patients with systemic sclerosis (SSc). Some of these cytokines also play an important role in the differentiation and migration of eosinophils. The aim of this study was to determine whether eosinophilic inflammation is caused in SSc. We retrospectively reviewed the peripheral blood eosinophil counts in 70 untreated patients with SSc and compared them with those in patients with other major collagen diseases. We additionally...
6 CitationsSource
#1Yasunori EnomotoH-Index: 17
#2Tamiko TakemuraH-Index: 43
Last. Takashi OguraH-Index: 55
view all 10 authors...
Introduction Interstitial lung disease associated with primary Sjogren’s syndrome (pSS–ILD) shows several patterns such as nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP). Although UIP is a well–recognized prognostic determinant in idiopathic interstitial pneumonias, whether this is also the case in pSS–ILD is unclear. The objectives of this study were to evaluate the prognostic effect of UIP, and to identify the prognostic factors in pSS–ILD.
40 CitationsSource
#1Øyvind Palm (Oslo University Hospital)H-Index: 22
#2Torhild Garen (Oslo University Hospital)H-Index: 23
Last. Jan Tore Gran (Oslo University Hospital)H-Index: 43
view all 7 authors...
OBJECTIVE: The aim of the present study was to describe the prevalence of clinical pulmonary manifestations in primary SS (pSS), and based on registry data, to assess quality of life (QoL) and mortality in these patients. METHODS: Patients with pSS consecutively included in the Norwegian systemic CTD and vasculitis registry (NOSVAR) were investigated for pulmonary manifestations when presenting with clinical pulmonary symptoms. Pulmonary involvement was defined as typical abnormalities identifie...
90 CitationsSource
#1Maria Kokosi (Sismanoglio General Hospital)H-Index: 1
#2Ellen C. Riemer (MUSC: Medical University of South Carolina)H-Index: 10
Last. Kristin B. Highland (MUSC: Medical University of South Carolina)H-Index: 27
view all 3 authors...
Sjogren syndrome is a slowly progressing autoimmune disease. Pulmonary manifestations are frequent in primary Sjogren syndrome but often not clinically significant; the most common are xerotrachea, interstitial lung diseases, and small airway obstruction. Pulmonary manifestations in Sjogren syndrome have a slow progression and favorable prognosis, with the exception of primary pulmonary lymphoma and pulmonary hypertension.
54 CitationsSource
#1Sherine E. Gabriel (UR: University of Rochester)H-Index: 102
#1Sherine E. Gabriel (UR: University of Rochester)H-Index: 10
Last. Kaleb Michaud (UNMC: University of Nebraska Medical Center)H-Index: 33
view all 2 authors...
Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juv...
613 CitationsSource
#1Takashi Ishiguro (Kanazawa University)H-Index: 17
#2Hideharu Kimura (Kanazawa University)H-Index: 21
Last. Masaki Fujimura (Kanazawa University)H-Index: 53
view all 8 authors...
We herein report an 80-year-old man with prostatic carcinoma who developed eosinophilic pneumonia and intrathoracic metastases. He presented with shortness of breath, cough, and fever as a chief complaint. Chest X-ray and computed tomography showed bilateral pulmonary nodules, intrathoracic lymphadenopathy, and right-sided consolidation. Positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) showed poor uptake in these nodules and lymph nodes. The patient subsequently received a p...
6 CitationsSource
#1Mahmood Alam (University of Connecticut Health Center)H-Index: 1
#2Nausherwan K. BurkiH-Index: 24
Chronic eosinophilic pneumonia (CEP) is a disease of unknown cause. The hallmark of CEP is eosinophil accumulation in the lungs. While the triggering factor is unknown, eosinophil accumulation in the lungs is now believed to be secondary to the actions of eosinophil-specific chemoattractants, including eotaxin and regulated upon activation, normal T-cell expressed and secreted (RANTES), and IL-5 released from Th2 lymphocytes in the lungs. There is a female preponderance in CEP, with a peak incid...
40 CitationsSource
#1Joseph G. Parambil (Mayo Clinic)H-Index: 11
#2Jeffrey L. Myers (UM: University of Michigan)H-Index: 60
Last. Jay H. Ryu (Mayo Clinic)H-Index: 101
view all 5 authors...
Background Primary Sjogren syndrome (pSS) has been associated with various histologic patterns of interstitial lung disease (ILD). Methods We retrospectively identified 18 patients with pSS and suspected ILD who underwent lung biopsies (14 surgical biopsies and 9 bronchoscopic biopsies) at our institution during a 13-year period from 1992 through 2004. Histopathologic findings were analyzed and correlated with radiologic features and outcome. Results Median age was 62 years (range, 34 to 78 year...
238 CitationsSource
#1Isao Ito (Kyoto University)H-Index: 29
#2Sonoko Nagai (Kyoto University)H-Index: 56
Last. Michiaki MishimaH-Index: 76
view all 10 authors...
Rationale: Clinicopathologic pulmonary manifestations associated with primary Sjogren's syndrome have yet to be reviewed in a large series since the recognition of nonspecific interstitial pneumonia (NSIP) as a distinct histologic pattern. Objectives: To determine clinical presentations, high-resolution computed tomographic (HRCT) and histologic findings of the lung disease associated with primary Sjogren's syndrome in the light of NSIP, and to analyze prognosis of the disease. Methods: On the b...
262 CitationsSource
Cited By2
Newest
#1Yuehui Liu (NCU: Nanchang University)H-Index: 1
#2Xinhua Zhu (NCU: Nanchang University)H-Index: 1
Last. Hao Zhang (NCU: Nanchang University)H-Index: 1
view all 3 authors...
The present study aimed to use RNA interference (RNAi) to silence chemokine receptor 3 (CCR3) and observe the effects on eosinophils (EOS) in mice with allergic rhinitis (AR). CCR3 small interfering RNA (siRNA) lentiviral vectors were transduced into purified EOS cells cultured in vitro. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot analyses were also used to detect the efficiency of silencing, and flow cytometry was used to detect the EOS apoptosis rates. Experimenta...
3 CitationsSource
#1Katsutoshi Ando (Juntendo University)H-Index: 11
#2Tamao NakashitaH-Index: 6
Last. Shinji MotojimaH-Index: 5
view all 5 authors...
Increased levels of serum pro-fibrotic cytokines have been reported in patients with systemic sclerosis (SSc). Some of these cytokines also play an important role in the differentiation and migration of eosinophils. The aim of this study was to determine whether eosinophilic inflammation is caused in SSc. We retrospectively reviewed the peripheral blood eosinophil counts in 70 untreated patients with SSc and compared them with those in patients with other major collagen diseases. We additionally...
6 CitationsSource