Oxidative Stress Signaling in Alzheimers Disease

Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimers disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role in AD. Oxidative stress not only temporally precedes the pathological lesions of the disease but also activates cell signaling pathways, which, in turn, contribute to lesion formation and, at the same time, provoke cellular responses such as compensatory...