Local Regulation of Gonadotroph Function by Pituitary Gonadotropin-Releasing Hormone
Abstract
Cultured rat pituitary cells and immortalized pituitary gonadotrophs (alphaT3-1 cells) express specific messenger RNA transcripts for GnRH and exhibit positive immunostaining for the GnRH peptide. Each cell type released GnRH during both static culture and perifusion, albeit in lesser amounts than cultured hypothalamic cells and GT1-7 neurons. In perifused pituitary cells, exposure to a GnRH agonist stimulated the release of GnRH as well as LH....
Paper Details
Title
Local Regulation of Gonadotroph Function by Pituitary Gonadotropin-Releasing Hormone
Published Date
Mar 1, 2000
Journal
Volume
141
Issue
3
Pages
1187 - 1195
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Notes
History