Last. Paul M. Yen(NUS: National University of Singapore)H-Index: 57
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Skeletal muscle (SM) weakness occurs in hypothyroidism and resistance to thyroid hormone alpha (RTHα) syndrome. However, the cell signaling and molecular mechanism(s) underlying muscle weakness under these conditions is not well understood. We thus examined the role of thyroid hormone receptor alpha (TRα), the predominant TR isoform in SM, on autophagy, mitochondrial biogenesis and metabolism to demonstrate the molecular mechanism(s) underlying muscle weakness in these two conditions.Two genetic...
Last. Craig A. Smith(Monash University, Clayton campus)H-Index: 58
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Reproduction in males requires the transfer of spermatozoa from testis tubules via the rete system to the efferent ductules, epididymis and vas deferens. The rete therefore forms an essential bridging system between the testis and excurrent ducts. Yet the embryonic origin and molecular regulation of rete testis development is poorly understood. This review examines the anatomy, endocrine control and development of the mammalian rete testis, focussing on recent findings on its molecular regulatio...
Last. Laura N. Vandenberg(UMass: University of Massachusetts Amherst)H-Index: 47
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The mammary gland is a hormone sensitive organ that is susceptible to endocrine disrupting chemicals (EDCs) during the vulnerable periods of parous reorganization (i.e. pregnancy, lactation, and involution). Pregnancy is believed to have long-term protective effects against breast cancer development, however, it is unknown if EDCs can alter this effect. We examined the long-term effects of propylparaben, a common preservative used in personal care products and foods, with estrogenic properties, ...
Corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus are the canonical controllers of the endocrine response to stress. Here we propose a new role for these cells as a gate for state transitions that allow the organism to engage in stress-related behaviors. Specifically, we review evidence indicating that activation of these cells at critical times allows organisms to move to a state that is permissive for motor action. This is evident when the organis...
Last. David P. Olson(UM: University of Michigan)H-Index: 35
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The paraventricular nucleus of the hypothalamus (PVH) is a heterogeneous collection of neurons that play important roles in modulating feeding and energy expenditure. Abnormal development or ablation of the PVH results in hyperphagic obesity and defects in energy expenditure whereas selective activation of defined PVH neuronal populations can suppress feeding and may promote energy expenditure. Here, we characterize the contribution of calcitonin receptor-expressing PVH neurons (CalcR PVH) to en...
Mineralocorticoid receptor (MR) antagonists (MRA), also referred to as aldosterone blockers, are now well recognised for their clinical benefit in patients with heart failure with reduced ejection fraction (HFrEF). Recent studies have also shown MRA can improve outcomes in patients with 'HFpEF', where the ejection fraction is preserved but left ventriclar filling is reduced. While the MR is a steroid hormone receptor best known for anti-natriuretic actions on electrolyte homeostasis in the dista...
#1Melissa E Lenert(UTD: University of Texas at Dallas)H-Index: 1
#2Amanda Avona(UTD: University of Texas at Dallas)H-Index: 4
Last. Michael D. Burton(UTD: University of Texas at Dallas)H-Index: 17
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The inclusion of females in preclinical pain studies has become more commonplace in the last decade, as the National Institutes of Health (NIH) "Sex as a Biological Variable" (SABV) mandate was released. Presumably, basic researchers have not had a comprehensive understanding about neuroimmune interactions in half of the population and how hormones play a role in this. To date, we have learned that sex hormones contribute to sexual differentiation of the nervous system and sex differences in beh...
#2Daisy Sahoo(MCW: Medical College of Wisconsin)H-Index: 18
Free fatty acids (FFAs) are implicated in the pathogenesis of metabolic diseases that include obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). FFAs serve as ligands for free fatty acid receptors (FFARs) that belong to the family of rhodopsin-like G protein-coupled receptors (GPCRs) and are expressed throughout the body to maintain energy homeostasis under changing nutritional conditions. Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120 (...