Cutaneous Uptake of14C-Hd Vapor By The Hairless Guinea Pig
Abstract
The hairless guinea pig (HGP) is used by our laboratory to model the human cutaneous response to sulfur mustard (HD), bis(2-chloroethylsulfide), exposure. We determined the HD content in the skin of HGP after a 7-min exposure to vapors saturated with a mixture of HD and l4C-HD. Concentration/time (CT) values in the range of 2 μg/cm2/min were determined by counting skin 14C disintegrations per min (dpm) in animals euthanized immediately after...
Paper Details
Title
Cutaneous Uptake of14C-Hd Vapor By The Hairless Guinea Pig
Published Date
Jan 1, 1999
Journal
Volume
22
Issue
2
Pages
375 - 387
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