Drug and Chemical Toxicology
Papers 2069
1 page of 207 pages (2,069 results)
#1Namkee G. Choi (University of Texas at Austin)H-Index: 36
#2Bryan Y. Choi (PCOM: Philadelphia College of Osteopathic Medicine)
Last. S David Baker (TU: Temple University)H-Index: 2
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High rates of opioid overdose and suicide among the 50+ age group call for an examination of suicidal intent in overdose incidents. Using 2015–2020 National Poison Data System opioid poisoning case...
#1Nastaran Khorashadizadeh (IAU: Islamic Azad University)
#2Ali Neamati (IAU: Islamic Azad University)H-Index: 7
Last. Leila Etemad (MUMS: Mashhad University of Medical Sciences)H-Index: 10
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Paraquat (PQ), one of the most frequently used herbicides, can cause serious health problems in an exposed individual. In the present study, we investigated the protective effect of verbascoside (VB), a phenylpropanoid glycoside from lemon verbena, against PQ-induced A549 cell injury with a particular focus on the possible molecular pathways involved. A549 cells were exposed to PQ (300 µM) and different concentrations of VB (12.5, 25, and 50 µM). Cell viability, ROS content, the level of antioxi...
Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixic acid. FQs are used against SARS-CoV-2 in our country, and for the treatment of some urinary tract diseases, gastrointestinal diseases, respiratory tract diseases, sexually transmitted diseases, and dermatological diseases. The present study investigated the effect of 1-,7-,14-day treatments of three different FQ derivatives; ciprofloxacin (CIP) 80 mg/kg/day, levofloxacin (LVX) 40 mg/kg/day, and mox...
#1Amine Hafis Abdelsalam (Pamukkale University)
#2Hasan Basri Ila (Çukurova University)H-Index: 7
Commiphora myrrha, located in the tropical zone, is a widely used tree for medicinal purposes in the Arabian Peninsula and a large part of Africa. In this research, cytogenotoxic effects of the com...
#1Luana Souza Amorim (UFPB: Federal University of Paraíba)
#2Pedro Everton Marques Goes (UFPB: Federal University of Paraíba)H-Index: 1
Last. Sabrina Garcia de Aquino (UFPB: Federal University of Paraíba)H-Index: 12
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This study evaluated the in vitro antimicrobial and immunomodulatory action of crude extracts from Anacardium occidentale L. (cashew tree) leaves and bark, and to determine their toxicity to peripheral-blood mononuclear cells (PBMCs) and to zebrafish embryos and larvae. Chemical analysis of extracts was performed by proton nuclear magnetic resonance (1H-NMR). The antibacterial activity was evaluated against selected bacteria strains by determining the minimum inhibitory concentration (MIC) and m...
#1Muhammet Yasin Tekeli (Erciyes University)H-Index: 2
#2Latife Çakir Bayram (Erciyes University)H-Index: 3
Last. Zeynep Soyer Sarica (Erciyes University)H-Index: 8
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The aim of this study was to investigate the protective efficacy of chrysin against propetamphos exposure. For this purpose, 2 to 3-month-old 40 male Wistar Albino rats were used. These animals were randomly assigned to four groups. The animals in the control group received the vehicle substance (corn oil) alone. Groups 2, 3 and 4 were administered with 50 mg/kg.bw/day of chrysin (in corn oil), 10 mg/kg.bw/day of propetamphos (in corn oil), and 10 mg/kg.bw/day of propetamphos plus 50 mg/kg.bw/da...
#1Olubukola T. Oyebode (UI: University of Ibadan)H-Index: 4
#2Amos O. Abolaji (UI: University of Ibadan)H-Index: 17
Last. Olufunso O. Olorunsogo (UI: University of Ibadan)H-Index: 12
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The present study investigated the antioxidant and cyto-/mito-protective roles of Methanol Fraction of Ficus mucoso (MFFM) in iron-induced oxidative damage in Drosophila melanogaster. At first, 10-day survival rates were carried out separately on FeSO4 and MFFM, respectively, after which ameliorative effects of MFFM were investigated on FeSO4-induced toxicity for 5 days using biochemical and behavioral markers. Additionally, mitochondria were isolated from treated D. melanogaster to assess mitoc...
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#1Mutlu Deger (Çukurova University)H-Index: 1
#2Bülent Kaya (Çukurova University)H-Index: 8
Last. Ibrahim Atilla Aridogan (Çukurova University)H-Index: 8
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This study aimed to reveal the possible protective effect of dapagliflozin (DAPA) against acute kidney damage due to cyclosporine A (CsA). Thirty-two mice with an eight-week-old Balb\c albino strain were divided into four groups: control group, CsA group, DAPA group, and CsA + DAPA group. On day 9 of treatment, the animals were decapitated, and bilateral nephrectomy was performed. Oxidative stress and apoptosis were evaluated with caspase-3 activity, total oxidant status (TOS), total antioxidant...
#1Ishfaq Shafi Khan (University of Kashmir)H-Index: 1
#2Shafat Ali (University of Kashmir)H-Index: 1
Last. Showkat Ahmad DarH-Index: 3
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Orange red is a food and cosmetic coloring agent made by the amalgamation of two azo dyes carmoisine and sunset yellow.The current study demonstrates the effect of different concentrations of orang...
#1Linlin Deng (ECUST: East China University of Science and Technology)
#2Mengyao Zhao (ECUST: East China University of Science and Technology)H-Index: 5
Last. Liming Zhao (ECUST: East China University of Science and Technology)H-Index: 13
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Acrylamide (ACR) is a potential neurotoxin commonly found in the environment, as well as in food repeatedly exposed heat processing, but the mechanism underpinning ACR-induced neurotoxicity remains...
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