Classic models for dynamic contrast‐enhanced MRI

Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T 1 ‐weighted MR images are acquired dynamically after bolus injection of a contrast agent. The data can be interpreted in terms of physiological tissue characteristics by applying the principles of tracer‐kinetic modelling. In the brain, DCE‐MRI enables measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), blood–brain barrier (BBB) permeability–surface...