NMR in Biomedicine
Papers 3,366
1 page of 337 pages (3,366 results)
#1Syver Døving Agdestein (École Polytechnique)
#2Try Nguyen TranH-Index: 2
Last. Jing-Rebecca Li (École Polytechnique)H-Index: 17
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The complex transverse water proton magnetization subject to diffusion-encoding magnetic field gradient pulses in a heterogeneous medium such as brain tissue can be modeled by the Bloch-Torrey partial differential equation. The spatial integral of the solution of this equation in realistic geometry provides a gold-standard reference model for the diffusion MRI signal arising from different tissue micro-structures of interest. A closed form representation of this reference diffusion MRI signal, c...
#1Jill J. Weyers (Sunnybrook Research Institute)H-Index: 8
#2Venkat Ramanan (Sunnybrook Research Institute)H-Index: 10
Last. Nilesh R. Ghugre (Sunnybrook Health Sciences Centre)H-Index: 19
view all 8 authors...
Stress imaging identifies ischemic myocardium by comparing hemodynamics during rest and hyperemic stress. Hyperemia affects multiple hemodynamic parameters in myocardium, including myocardial blood flow (MBF), myocardial blood volume (MBV), and venous blood oxygen levels (PvO2 ). Cardiac T2 is sensitive to these changes and therefore is a promising non-contrast option for stress imaging; however, the impact of individual hemodynamic factors on T2 is poorly understood, making the connection from ...
#1Zheng Han (ICSCI: Kennedy Krieger Institute)H-Index: 15
#2Chuheng Chen (Case Western Reserve University)
Last. Guanshu Liu (ICSCI: Kennedy Krieger Institute)H-Index: 36
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Natural and synthetic sugars have great potential for developing highly biocompatible and translatable chemical exchange saturation transfer (CEST) MRI contrast agents. In this study, we aimed to develop the smallest clinically available form of dextran, Dex1 (molecular weight, MW ~ 1 kDa), as a new CEST agent. We first characterized the CEST properties of Dex1 in vitro at 11.7 T and showed that the Dex1 had a detectable CEST signal at ~1.2 ppm, attributed to hydroxyl protons. In vivo CEST MRI s...
#1Tanay Chougule (Symbiosis International University)H-Index: 3
#2Rakesh Kumar Gupta (Fortis Healthcare)H-Index: 2
Last. Madhura Ingalhalikar (Symbiosis International University)H-Index: 14
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Glioblastoma is a highly infiltrative neoplasm with a high propensity of recurrence. The location of recurrence usually cannot be anticipated and depends on various factors, including the surgical resection margins. Currently, radiation planning utilizes the hyperintense signal from T2-FLAIR MRI and is delivered to a limited area defined by standardized guidelines. To this end, noninvasive early prediction and delineation of recurrence can aid in tailored targeted therapy, which may potentially ...
#1Jianpan Huang (CityU: City University of Hong Kong)H-Index: 7
#2Joseph H. C. Lai (CityU: City University of Hong Kong)H-Index: 2
Last. Kannie W.Y. ChanH-Index: 24
view all 9 authors...
We investigated three dynamic glucose-enhanced (DGE) MRI methods for sensitively monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF) at clinical field strength (3 T). By comparing three sequences, namely, Carr-Purcell-Meiboom-Gill (CPMG), on-resonance variable delay multipulse (onVDMP), and on-resonance spin-lock (onSL), a high-sensitivity DGE MRI scheme with truncated multilinear singular value decomposition (MLSVD) denoising was proposed. The CPMG met...
#1Julia Debik (NTNU: Norwegian University of Science and Technology)H-Index: 4
#2Matteo Sangermani (NTNU: Norwegian University of Science and Technology)H-Index: 4
Last. Guro F. Giskeødegård (NTNU: Norwegian University of Science and Technology)H-Index: 19
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Nuclear magnetic resonance (NMR) spectroscopy allows for simultaneous detection of a wide range of metabolites and lipids. As metabolites act together in complex metabolic networks, they are often highly correlated, and optimal biological insight is achieved when using methods that take the correlation into account. For this reason, latent-variable-based methods, such as principal component analysis and partial least-squares discriminant analysis, are widely used in metabolomic studies. However,...
#1H. T. Cho (UNIST: Ulsan National Institute of Science and Technology)H-Index: 2
#2Hansol Lee (UNIST: Ulsan National Institute of Science and Technology)H-Index: 7
Last. HyungJoon Cho (UNIST: Ulsan National Institute of Science and Technology)H-Index: 20
view all 6 authors...
In studies of the white matter (WM) in aging brains, both quantitative susceptibility mapping (QSM) and direct R1 measurement offer potentially useful ex vivo MRI tools that allow volumetric characterization of myelin content changes. Despite the technical importance of such MRI methods in numerous age-related diseases, the supposed linear relationship between the estimates of either the QSM or R1 method and age-affected myelin contents has not been validated. In this study, the absolute myelin ...
#1Chun-Jung JuanH-Index: 19
#2Teng-Yi Huang (NTUST: National Taiwan University of Science and Technology)H-Index: 13
Last. Ruey-Feng Chang (NTU: National Taiwan University)
view all 8 authors...
In this study, the performance of machine learning in classifying parotid gland tumors based on diffusion-related features obtained from the parotid gland tumor, the peritumor parotid gland, and the contralateral parotid gland was evaluated. Seventy-eight patients participated in this study and underwent magnetic resonance diffusion-weighted imaging. Three regions of interest, including the parotid gland tumor, the peritumor parotid gland, and the contralateral parotid gland, were manually conto...
#1Abdullah Sarray Bdaiwi (UC: University of Cincinnati)H-Index: 1
#2Peter J. Niedbalski (Boston Children's Hospital)
Last. Zackary I. Cleveland (UC: University of Cincinnati)H-Index: 18
view all 10 authors...
RATIONALE Hyperpolarized (HP) 129 Xe-MRI provides non-invasive methods to quantify lung function and structure, with the 129 Xe apparent diffusion coefficient (ADC) being a well validated measure of alveolar airspace size. However, the experimental factors that impact the precision and accuracy of HP 129 Xe ADC measurements have not been rigorously investigated. Here, we introduce an analytical model to predict the experimental uncertainty of 129 Xe ADC estimates. Additionally, we report ADC dep...
#1Li E. Lee (MU: University of Missouri)
#2Bysani Chandrasekar (MU: University of Missouri)H-Index: 55
Last. Lixin Ma (MU: University of Missouri)H-Index: 99
view all 4 authors...
Noninvasive imaging of cardiac fibrosis is important for early diagnosis and intervention in chronic heart diseases. Here, we investigated whether noninvasive, contrast agent-free MRI T2 -mapping can quantify myocardial fibrosis in preclinical models of aging and pressure overload. Myocardial fibrosis and remodeling were analyzed in two animal models: (i) aging (15-month-old male CF-1 mice vs. young 6- to 8-week-old mice), and (ii) pressure overload (PO; by transverse aortic constriction in 4- t...
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