Oxidized extracellular DNA as a stress signal that may modify response to anticancer therapy
Abstract
An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can be released in circulation (cfDNA). According to the results of the studies performed in vitro by our group and other researchers, the oxidized cfDNA serves as a biomarker for a stress and a stress signal that is transmitted from the “stressed” area i.e....
Paper Details
Title
Oxidized extracellular DNA as a stress signal that may modify response to anticancer therapy
Published Date
Jan 1, 2015
Journal
Volume
356
Issue
1
Pages
22 - 33
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