Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes
Abstract
In vascular smooth muscle, store-operated channels (SOCs) contribute to many physiological functions including vasoconstriction and cell growth and proliferation. In the present work we compared the properties of SOCs in freshly dispersed myocytes from rabbit coronary and mesenteric arteries and portal vein. Cyclopiazonic acid (CPA)-induced whole-cell SOC currents were sixfold greater at negative membrane potentials and displayed markedly...
Paper Details
Title
Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes
Published Date
May 15, 2008
Journal
Volume
586
Issue
10
Pages
2463 - 2476
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Notes
History