The Journal of Physiology
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#1Davide Momi (University of Chieti-Pescara)H-Index: 9
#2Recep Ali Ozdemir (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 12
Last. Emiliano Santarnecchi (Harvard University)H-Index: 32
view all 9 authors...
Key points null Synchronized TMS pulses with pre-defined brain oscillatory phases allows to evaluate the impact of brain states on TMS effects. TMS pulses over M1 at the negative peak of μ-frequency band induces higher phase-lock synchronization with interconnected contralateral homologous regions. Cortico-cortical synchronization changes are linearly predicted by the fiber density and cross-section of the white matter tract that connect the two brain regions. Phase-dependent TMS delivery might ...
#1Kiel G. Ormerod (Picower Institute for Learning and Memory)H-Index: 10
#2Anthony E. Scibelli (Tufts University)H-Index: 1
Last. J. Troy Littleton (Picower Institute for Learning and Memory)H-Index: 42
view all 3 authors...
Key points null Larval muscle contraction force increases with stimulation frequency and duration, revealing substantial plasticity between 5 and 40 Hz. Fictive contraction recordings demonstrate endogenous motoneuron burst frequencies consistent with the neuromuscular system operating within the range of greatest plasticity. Genetic and pharmacological manipulation of critical components of pre- and post-synaptic Ca2+ regulation significantly impact the strength and time-course of muscle contra...
#1Yuvraj Joshi (French Institute of Health and Medical Research)H-Index: 1
#2Chloé P Petit (French Institute of Health and Medical Research)
Last. Régis Nouvian (French Institute of Health and Medical Research)H-Index: 19
view all 11 authors...
Key points null The vesicular glutamate transporter type 3 (VGLUT3) loads glutamate into synaptic vesicles of auditory sensory cells, the inner hair cells (IHCs). The VGLUT3-p.A211V variant is associated with the human deafness DFNA25 Mutant mice carrying the VGLUT3-p.A211V variant show a progressive hearing loss. IHCs from mutant mice harbor distorted stereocilary bundles, which detect incoming sound-stimulation followed by oversized synaptic ribbons, which release glutamate onto the afferent n...
#1Yasra Arif (UNMC: University of Nebraska Medical Center)H-Index: 2
#2Rachel K. Spooner (UNMC: University of Nebraska Medical Center)H-Index: 7
Last. Tony W. Wilson (Boys Town)H-Index: 33
view all 4 authors...
Key points null Logical reasoning is an indispensable component of fluid intelligence and involves multispectral oscillatory activity in parietal and frontal regions. Parieto-frontal integration is well characterized in logical reasoning; however, its direct neural quantification and neuromodulation by brain stimulation remain poorly understood. High-definition transcranial direct current stimulation of dorsolateral prefrontal cortex (DLPFC) had modulatory effects on task performance and neural ...
#1Robert T. R. Huckstepp (Warw.: University of Warwick)H-Index: 12
#2Gregory D. Funk (U of A: University of Alberta)H-Index: 38
#1Raquel de Sousa Abreu (UCLA: University of California, Los Angeles)H-Index: 8
As neuronal subtypes are increasingly categorized, delineating their functional role is paramount. The preBotzinger Complex (preBotC) subpopulation expressing the neuropeptide somatostatin (SST) is classified as mostly excitatory, inspiratory-modulated and not rhythmogenic. We further characterized their phenotypic identity; 87% were glutamatergic and the balance were glycinergic and/or GABAergic. We then used optogenetics to investigate their modulatory role in both anesthetized and freely movi...
#1Didu Kariyawasam (UNSW: University of New South Wales)H-Index: 3
#2Arlene D’Silva (UNSW: University of New South Wales)H-Index: 4
Last. Cindy S.-Y. Lin (USYD: University of Sydney)H-Index: 38
view all 8 authors...
Spinal muscular atrophy (SMA) is associated with developmental disruption of motor axons in ventral roots of the spinal cord alongside motor axon degeneration. The pathogenesis of peripheral axonal change during development is pertinent to understand treatment response. Nerve excitability techniques, stimulating the median motor nerve at the wrist, were utilised to investigate axonal change during neurodevelopment in 24 children with SMA, compared with 71 age-matched controls. Longitudinal axona...
#1Brett L. Cross (GS: Georgia Southern University)H-Index: 1
#2Joseph D. Vondrasek (GS: Georgia Southern University)
Last. Zoe R. Lincoln (GS: Georgia Southern University)
view all 5 authors...
#1Matthew Yedutenko (Netherlands Institute for Neuroscience)
#2Marcus H. C. Howlett (Netherlands Institute for Neuroscience)H-Index: 11
Last. Maarten Kamermans (Netherlands Institute for Neuroscience)H-Index: 34
view all 3 authors...
KEY POINTS Humans can discriminate visual scenes based on skewness - the relative prevalence of bright and dark patches within a scene. Here we show negatively skewed time-series stimuli induce larger responses in goldfish cone photoreceptors than comparable positively skewed stimuli. This response asymmetry originates from within the phototransduction cascade, where gain is higher for strong negative contrasts (dark patches) than for strong positive (bright patches) contrasts. Unlike the implic...
#1Mamoru Tanaka (Dodai: Doshisha University)
#2Takeshi Sakaba (Dodai: Doshisha University)H-Index: 29
Last. Takafumi Miki (Dodai: Doshisha University)H-Index: 4
view all 3 authors...
Before fusion, synaptic vesicles (SVs) pause at discrete release/docking sites. During repetitive stimulation, the probability of site occupancy changes following SV fusion and replenishment. The occupancy probability is considered to be one of the crucial determinants of synaptic strength, but it is difficult to estimate separately because it usually blends with other synaptic parameters. Thus, the contribution of site occupancy to synaptic function, particularly to synaptic depression, remains...
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