KIT Gene Mutations and Copy Number in Melanoma Subtypes
Abstract
Purpose: We recently identified a KIT exon 11 mutation in an anorectal melanoma of a patient who had an excellent response to treatment with imatinib. To determine the frequency of KIT mutations across melanoma subtypes, we surveyed a large series of tumors. Experimental Design: One hundred eighty-nine melanomas were screened for mutations in KIT exons 11, 13, and 17. KIT copy number was assessed by quantitative PCR. A subset of cases was...
Paper Details
Title
KIT Gene Mutations and Copy Number in Melanoma Subtypes
Published Date
Nov 1, 2008
Journal
Volume
14
Issue
21
Pages
6821 - 6828
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