Original paper
Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer
Abstract
Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are located within exons 18-21. The -216 single nucleotide polymorphism in the promoter region is associated with increased EGFR production. We present a method for detecting these common mutations in 81 cases of NSCLC. The protocol is based on...
Paper Details
Title
Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer
Published Date
May 12, 2010
Volume
17
Issue
1
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