Induction of Interferon Regulatory Factor 1 Expression in Human Dermal Endothelial Cells by Interferon-γ and Tumor Necrosis Factor-α Is Transcriptionally Regulated and Requires Iron

Interferon regulatory factor-1 is a transcription factor that is linked to the expression of genes important in the initiation of the inflammatory response and the control of cell cycle. In this study, we determined that the generation of interferon regulatory factor-1 expression in human dermal microvascular endothelial cells was transcriptionally mediated by tumor necrosis factor-α or interferon-γ via iron-dependent pathways. The induction of...