Last. Wei-Meng Woo(NTU: Nanyang Technological University)
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The Hedgehog (Hh) pathway is essential for animal development but aberrant activation promotes cancer growth. Here we show that GIPC3, a PDZ domain-containing protein with putative adaptor protein function, positively modulates Hh target gene expression in normal fibroblasts and melanoma cells and supports melanoma tumor growth. Using overexpression and epistasis studies, we show that Gipc3 potentiates Hh transcriptional output and it modulates GLI-dependent transcription independently of Sufu. ...
#1Emily Y. Chu(UPenn: University of Pennsylvania)H-Index: 22
#2Junko Takeshita(UPenn: University of Pennsylvania)H-Index: 24
Last. Michael E. Ming(UPenn: University of Pennsylvania)H-Index: 26
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The article by Shah et al. (2021) published in the Journal of Investigative Dermatology adds to the growing body of literature on disparities in melanoma care. The authors report that whereas melanoma is more common in the New York state's counties with higher socioeconomic status (SES) and increased health-system access (HSA), counties with lower SES and decreased HSA have a relatively increased proportion of late-stage melanoma diagnoses. Increased understanding of the individual- and communit...
#1Renuka R. Nayak(UCSF: University of California, San Francisco)H-Index: 9
Shi et al. (2021) in "Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice" show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulat...
Last. Ryan R. Driskell(WSU: Washington State University)H-Index: 23
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Single-cell RNA sequencing (scRNA-seq) provides an unprecedented ability to investigate cellular heterogeneity in entire organs and tissues, including human skin. Ascension et al. (2020) combined and reanalyzed human skin scRNA-seq datasets to uncover new insights into fibroblast heterogeneity. This work demonstrates that new discoveries can be made from published data on the basis of principles of these three Rs: Reuse, Refine, and Resource.
The scientific process depends on social interactions: communication and dissemination of research findings, evaluation and discussion of scientific work, and collaboration with other scientists. Social media, and specifically, Twitter has accelerated the ability to accomplish these goals. We discuss the ways that Twitter is used by scientists and provide guidance on navigating the academic Twitter community.
#2John T. Seykora(UPenn: University of Pennsylvania)H-Index: 33
Most cutaneous squamous cell carcinomas (cSCCs) arise from actinic keratoses (AKs), making these premalignant lesions attractive targets for therapeutic intervention before transformation. In a new article of the Journal of Investigative Dermatology, Thomson et al. (2021) characterize the genetic alterations in AKs and identify significantly mutated drivers associated with risk factors such as UVR or azathioprine along with signaling pathways that may regulate the progression from AK to cSCC.
Last. Márta Széll(University of Szeged)H-Index: 19
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Abstract null null In the last two decades, large-scale gene-expression studies on psoriatic skin samples revealed that even though non-lesional skin is macroscopically identical to healthy skin, it harbors several molecular differences. Originally, these molecular differences were thought to represent susceptibility factors for plaque formation. However, we review here several factors of immune regulation and structural alteration that are specific for the non-lesional skin and serve as protect...
Last. Tamar Golan(TAU: Tel Aviv University)H-Index: 11
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Abstract null null Almost half of human miRNAs are encoded in clusters. Although transcribed as a single unit, the levels of individual mature miRNAs often differ. The mechanisms underlying differential biogenesis of clustered miRNAs and the resulting physiological implications are mostly unknown. Here, we report that the melanoma master transcription regulator MITF regulates the differential expression of the 99a/let-7c/125b-2 cluster by altering the distribution of RNA polymerase II (Pol-II) a...