Chromatin structure and expression of the AMPA receptor subunit GluR2 in human glioma cells and the role of REST

The AMPA receptors are postsynaptic ion channels that open following stimulation with glutamate. The regulatory region of the gene encoding the GluR2 subtype of AMPA receptors contains a binding site for the transcriptional repressor REST. The cell-type specific microenvironment, in particular the cell type-specific structure of the chromatin, is crucial for the ability of REST to control target gene transcription. Using antibodies directed...