Cell Communication and Signaling
Papers 1128
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#1Xueqiong Meng (HAUST: Henan University of Science and Technology)
#2Yixiang Chen (HAUST: Henan University of Science and Technology)H-Index: 2
Last. Keith N. Leppard (Warw.: University of Warwick)H-Index: 23
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Background null The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which the multiple isoforms of PML protein participate in this process remain not well-understood. We previously demonstrated that PML isoform II (PML-II) positively regulates induced gene expression during a type I IFN response and evaluate here how PML-II contributes to IFNα-induced cell death. null Methods null HeLa cells wer...
#1Kwan Long Mung (UTU: University of Turku)H-Index: 1
#2William B. Eccleshall (Åbo Akademi University)
Last. Päivi J. Koskinen (UTU: University of Turku)H-Index: 25
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Background null The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kinases interact with each other to influence AMPK activation and tumorigenic growth of prostate and breast cancer cells. null Methods null We first determined how PIM and LKB1 kinases affect AMPK phosphorylation levels. We then used in vitro kinase assays to demonstrate that LK...
#1Maria A. Ortiz (State University of New York Upstate Medical University)H-Index: 2
#2Tatiana Mikhailova (State University of New York Upstate Medical University)
Last. Leszek Kotula (State University of New York Upstate Medical University)H-Index: 22
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Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms throug...
BACKGROUND Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are needed. Qualities of the tumor microenvironment as well as cancer cell secretion have independently been associated with malignant clinical behaviors and a better understanding of the interplay between these two features could potentially reveal novel targetable key events linked to cancer progression. METHODS A newly developed ...
Background null Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the formation of biomolecular condensates frequently contain oligomerization domains and intrinsically disordered regions (IDRs), both of which can contribute multivalent interactions that drive higher-order assembly. Our understanding of the relative and temporal contribution of...
#1Alessia Varone (National Research Council)H-Index: 6
#2Chiara Amoruso (National Research Council)
Last. Daniela Corda (National Research Council)H-Index: 46
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BACKGROUND Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia formation and activity is central for the prevention of tumor spreading and growth. Protein tyrosine kinases such as Src are known to regulate invadopodia assembly, little is however known on the role of protein tyrosine phosphatases in this process. Among these enzymes, we have selec...
BACKGROUND Human airway epithelial (HAE) cellular models are widely used in applicative studies of the airway physiology and disease. In vitro expanded and differentiated primary HAE cells collected from patients seem to be an accurate model of human airway, offering a quicker and cheaper alternative to the induced pluripotent stem cell (iPSCs) models. However, the biggest drawback of primary HAE models is their limited proliferative lifespan in culture. Much work has been devoted to understand ...
#2Nabila Bourebaba (International Institute of Minnesota)
Last. Lynda Bourebaba (International Institute of Minnesota)
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BACKGROUND Chronic superphysiological glucose and insulin concentrations are known to trigger several tissue and organ failures, including insulin resistance, oxidative stress and chronic low-grade inflammation. Hence, the screening for molecules that may counteract such conditions is essential in current existing therapeutic strategies, thereby the use of medicinal plant derivatives represents a promising axis in this regard. METHODS In this study, the effect of a selected traditional medicinal...
#1Juane Lu (TUC: Tianjin University of Commerce)
#2Tao Wu (TUC: Tianjin University of Commerce)
Last. Haihua Ruan (TUC: Tianjin University of Commerce)
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Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and...
#1Jillian Hattaway Luttman (Duke University)
#2Ashley Colemon (Duke University)
Last. Ann Marie Pendergast (Duke University)H-Index: 58
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The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation are due in part to ABL-dependent regulation of diverse cellular processes related to the epithelial to mesenchymal transition and subsequent steps in the metastatic cascade. ABL kinases target multiple signaling...
Top fields of study
Molecular biology
Cancer research
Signal transduction
Cell biology