Cell Communication and Signaling
Papers 1,178
1 page of 118 pages (1,178 results)
#1Hong-Bo Li (ZJU: Zhejiang University)
#2Zi-Han Yang (ZJU: Zhejiang University)
Last. Qing-Qu Guo (ZJU: Zhejiang University)
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Pancreatic cancer is an extremely malignant tumor with the lowest 5-year survival rate among all tumors. Pancreatic ductal adenocarcinoma (PDAC), as the most common pathological subtype of pancreatic cancer, usually has poor therapeutic results. Immune checkpoint inhibitors (ICIs) can relieve failure of the tumor-killing effect of immune effector cells caused by immune checkpoints. Therefore, they have been used as a novel treatment for many solid tumors. However, PDAC is not sensitive to monoth...
#2Miljan KuljaninH-Index: 10
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Background null Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 deficiency leads to calcium homeostasis disturbances and can change mitochondrial dynamics. The aim of this study was to evaluate protein levels and changes in gene transcription on human WFS cell model under experimental ER stress. null Methods null We performed transcriptomic...
#1Qiancheng ShiH-Index: 2
#2Liu Ning (NMU: Nanjing Medical University)
Last. Weidong Gan (NU: Nanjing University)H-Index: 15
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Background null Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be a factor influencing TFE3 breaks, and the topoisomerase II (TOP2) poison is considered one of the important risk factors in mediating DNA breaks. In this study, we investigated the potential pathogenesis of Xp11.2 tRCC using the renal epithelial cell line HK-2. null Metho...
#1He-Nan Zhou (Army Medical University)H-Index: 2
#2Dan-yang Zheng (Army Medical University)H-Index: 2
Last. Liangming Liu (Army Medical University)H-Index: 16
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BACKGROUND It is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently pericyte-derived microvesicles (PMVs) were confirmed to be therapeutic in many diseases, whether PMVs can protect vascular endothelial cell (VEC) injury is unknown. METHODS Pericytes were extracted from the retina of newly weaned rats, and PMVs were collected after starvation and characterized by flow-cytometry and transmission electron microscopy. First, t...
#1Ya Fan (NMU: Nanjing Medical University)H-Index: 1
#2Jia Wang (Dalian Medical University)H-Index: 3
Last. Dongming Su (NMU: Nanjing Medical University)H-Index: 20
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#1Wei Yang (Army Medical University)H-Index: 3
#2Yan Xiang (Army Medical University)H-Index: 5
Last. Sheng-Qing Lv (Army Medical University)H-Index: 13
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Background null Alzheimer's disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Presenilin1 represses cell proliferation by inhibiting the Wnt/β-catenin pathway in glioblastoma. However, the function of Presenilin1 and the underlying mechanism need to be further investigated. null Methods null The correlations of two genes were conducted on the R2 microarr...
#1Jing Li (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 1
#2Shengqi Wang (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 14
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#1Pia GiovannelliH-Index: 17
#2Marzia Di DonatoH-Index: 16
Last. Gabriella CastoriaH-Index: 33
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Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low risk of recurrence have a favourable outcome. In a substantial proportion of patients, however, the disease progresses and becomes aggressive. The mechanisms that promote prostate cancer progression remain still debated. Many findings point to the role of cross-communication between prostate ...
#1Sabine Bernegger (PLUS: University of Salzburg)H-Index: 3
#2Robert Vidmar (IJS: Jožef Stefan Institute)H-Index: 10
Last. Silja Wessler (PLUS: University of Salzburg)H-Index: 31
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BACKGROUND High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial cells was identified as the first HtrA substrate. HtrA-mediated hCdh1 cleavage and subsequent disruption of intercellular adhesions are considered as important steps in H. pylori pathogenesis. In this study, we performed a proteomic pr...
#1Katarzyna Kornicka-Garbowska (International Institute of Minnesota)H-Index: 6
#2Lynda Bourebaba (WUELS: Wroclaw University of Environmental and Life Sciences)H-Index: 7
Last. Krzysztof Marycz (International Institute of Minnesota)H-Index: 27
view all 4 authors...
BACKGROUND Protein tyrosine phosphatase 1B (PTP1B) and low molecular weight protein tyrosine phosphatase (LMPTP) are implicated in the development of metabolic disorders. Yet, their role in progenitor stem cell adipogenic differentiation and modulation of mitochondrial dynamics remains elusive. METHODS In this study, we decided to investigate whether inhibition of PTP1B and LMPTP enhance adipogenic differentiation of metabolically impaired progenitor stem cells via modulation of mitochondrial bi...
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