Connexin43 deficiency causes dysregulation of coronary vasculogenesis
Abstract
The connexin43 knockout (Cx43α1 KO) mouse dies at birth from outflow obstruction associated with infundibular pouches. To elucidate the origin of the infundibular pouches, we used microarray analysis to investigate gene expression changes in the pouch tissue. We found elevated expression of many genes encoding markers for vascular smooth muscle (VSM), endothelial cells, and fibroblasts, cell types that are epicardially derived and essential for...
Paper Details
Title
Connexin43 deficiency causes dysregulation of coronary vasculogenesis
Published Date
Aug 1, 2005
Journal
Volume
284
Issue
2
Pages
479 - 498
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