A case–control study provides evidence of association for a functional polymorphism −197C/G in XBP1 to schizophrenia and suggests a sex-dependent effect

Schizophrenia and bipolar disorder are two major psychiatric illnesses that may share specific genetic risk factors to a certain extent. Increasing evidence suggests that the two disorders might be more closely related than previously considered. In order to test this hypothesis, we investigated a functional polymorphism −197C/G in XBP1, which was reported to increase the risk of bipolar disorder, in a case–control study (374 cases vs. 371...