Velocardiofacial Syndrome in Childhood-Onset Schizophrenia

Deletion of chromosome 22q11 (velocardiofacial syndrome) is associated with early neurodevelopmental abnormalities and with schizophrenia in adults. The rate of 22q11 deletions was examined in a series of patients with childhood-onset schizophrenia (COS), in whom early premorbid developmental and cognitive impairments are more pronounced than in adult-onset cases.Through extensive recruiting and screening, a cohort of 47 patients was enrolled in...