A novel cell support membrane for skin tissue engineering: Gelatin film cross-linked with 2-chloro-1-methylpyridinium iodide

A novel method for preparing cell support membrane which employs heterogeneously cross-linking (CR) process to prepare water-insoluble gelatin (GEL) films was suggested, and compared with 1-ethyl-(3,3-dimethylaminopropyl)carbodiimide. In this study, we found that 2-chloro-1-methylpyridinium iodide (CMPI) is an effective zero-length cross-linker of gelatin, and showed a superior activation ability of carboxylic acid sodium salt under...