Different causes of Reduced Sensitivity to Thyroid Hormone: Diagnosis and Clinical management

Summary Normal thyroid hormone ( TH ) metabolism and action require adequate cellular TH signalling. This entails proper function of TH transporters in the plasma membrane, intracellular deiodination of TH and action of the bioactive hormone T3 at its nuclear receptors ( TR s). The present review summarizes the discoveries of different syndromes with reduced sensitivity at the cellular level. Mutations in the TH transporter MCT 8 cause...