Clinical Endocrinology
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#1Lisa Oest (HHU: University of Düsseldorf)
#2Michael Roden (HHU: University of Düsseldorf)H-Index: 103
Last. K MüssigH-Index: 21
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Objective null Insulin autoimmune syndrome (IAS) is the third most common cause of spontaneous hypoglycaemia in Japan but very rare in the rest of the world. We aimed to identify factors, which are associated with the occurrence of IAS and which may differ between East Asian and non-East Asian patients. null Design null A PubMed search using the search terms 'insulin autoimmune syndrome' and 'Hirata disease' revealed a total of 287 reports of IAS cases, including one previously unpublished own c...
OBJECTIVE The aim of the study was to investigate a new possible background of increased risk of cardiovascular events in two forms of endocrine hypertension: in primary aldosteronism (PA) and pheochromocytoma/paraganglioma (PPGL) in comparison to essential hypertension (EHT). CONTEXT Prothrombotic properties of the fibrin clot structure, impaired fibrinolysis and enhanced thrombin generation have been reported to be associated with increased cardiovascular risk. DESIGN Patients with PA and PPGL...
#1Di Li (CDC: Centers for Disease Control and Prevention)H-Index: 3
#2Boxian Zhang (CDC: Centers for Disease Control and Prevention)H-Index: 1
Last. Li Zhou (CDC: Centers for Disease Control and Prevention)H-Index: 20
view all 7 authors...
Objective null To explore the association between obesity and precocious puberty from the perspective of genetic polymorphism. null Design null Two hundred and ninety-eight pairs of girls in early puberty and age-matched controls (±3 months) were recruited. The genotypes of four obesity-related single-nucleotide polymorphism (SNP) loci (rs10968576, rs12935153, rs4674340 and rs7635103) were determined and the effect of variation on early puberty in Chinese Han girls was evaluated. The unstimulate...
#1Stefanie Parisien-La Salle (UdeM: Université de Montréal)H-Index: 3
#2Nadine DumasH-Index: 3
Last. Isabelle Bourdeau (UdeM: Université de Montréal)H-Index: 34
view all 10 authors...
Objective null Pheochromocytomas (PHEOs) and paragangliomas (PGLs), collectively known as PPGLs, are tumours with high heritability. The prevalence of germline mutations in apparently sporadic PPGLs varies depending on the study population. The objective of this study was to determine the spectrum of germline mutations in a cohort of patients with apparently sporadic PPGLs over time. null Design null We performed a retrospective review of patients with apparently sporadic PPGLs who underwent gen...
#1Louise Apperley (Boston Children's Hospital)H-Index: 3
#2James Blackburn (QMUL: Queen Mary University of London)H-Index: 2
Last. Senthil Senniappan (Boston Children's Hospital)H-Index: 14
view all 6 authors...
Obesity is becoming increasingly prevalent in paediatric populations worldwide. In addition to increasing prevalence, the severity of obesity is also continuing to rise. Taken together, these findings demonstrate a worrying trend and highlight one of the most significant challenges to public health. Childhood obesity affects multiple organs in the body and is associated with both significant morbidity and ultimately premature mortality. The prevalence of complications associated with obesity, in...
#1Juliane Lippert (University of Würzburg)H-Index: 3
#2Martin Fassnacht (University of Würzburg)H-Index: 83
Last. Cristina L Ronchi (University of Würzburg)H-Index: 21
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Adrenocortical carcinoma (ACC) is a rare, aggressive cancer with still partially unknown pathogenesis, heterogenous clinical behaviour and no effective treatment for advanced stages. Therefore, there is an urgent clinical unmet need for better prognostication strategies, innovative therapies and significant improvement of the management of the individual patients. In this review, we summarize available studies on molecular prognostic markers and markers predictive of response to standard therapi...
#1Mikiko Koizumi (Boston Children's Hospital)H-Index: 2
#2Ayako Konishi (Boston Children's Hospital)H-Index: 1
Last. Masanobu Kawai (Boston Children's Hospital)H-Index: 27
view all 5 authors...
OBJECTIVE Insulin growth factor-1 (IGF-1) is used to evaluate growth hormone (GH) sufficiency and is decreased in children with Prader-Willi syndrome (PWS). Although IGF-1 is negatively affected by body size and nutritional status, both of which are impaired in PWS children, these variables are typically not considered when assessing IGF-1 levels in these subjects. Here, we compared IGF-1 levels in PWS children to controls matched for age, sex, anthropometric parameters, and nutritional status. ...
#1Johannes Riis (AAU: Aalborg University)H-Index: 3
#2Stine Linding Andersen (AAU: Aalborg University)H-Index: 22
Last. Stig Andersen (AAU: Aalborg University)H-Index: 34
view all 8 authors...
OBJECTIVE A transient rise in the occurrence of hyperthyroidism ensued the introduction of iodine fortification (IF) of salt in Denmark. Older adults are at risk of complications to hyperthyroidism that could prove fatal to vulnerable individuals. We evaluated the association between thyroid function and mortality in older adults before and after nationwide implementation of IF. DESIGN Retrospective cohort study. PATIENTS All 68-year-olds from the general population in the city of Randers were i...
#1Jinghong Zhang (Monash University, Clayton campus)
#2Renata Libianto (Monash University, Clayton campus)H-Index: 6
Last. Jun Yang (Monash University, Clayton campus)H-Index: 13
view all 7 authors...
Background null The preoperative use of mineralocorticoid receptor antagonists (MRA) in patients with unilateral forms of primary aldosteronism (PA) is not standardized. The current Endocrine Society Guidelines do not specifically recommend MRA treatment before surgery. It is unclear whether preoperative MRA can optimize perioperative blood pressure and potassium control, and reduce the incidence of postoperative hyperkalaemia. null Objective null This study aimed to investigate the effect of MR...
#1Chang Ho Ahn (New Generation University College)H-Index: 9
#2Hee Young Na (New Generation University College)
Last. Jung Hee Kim (Seoul National University Hospital)H-Index: 24
view all 10 authors...
OBJECTIVE Primary aldosteronism (PA) shows histological heterogeneity and clinical variability, including the coexistence of hypercortisolemia. Immunohistochemical analyses of steroidogenic enzymes in adrenal tissues have provided new insights into the pathogenesis of PA. However, a comprehensive analysis of the association between enzyme expression and clinical characteristics of PA has rarely been conducted. We aimed to investigate the correlation between clinical characteristics and steroidog...
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