Cerebrospinal fluid immunological biomarkers associated with axonal damage in multiple sclerosis

Background and purpose Cerebrospinal fluid ( CSF ) neurofilament light protein ( NFL ) is a promising biomarker of axonal injury and neurodegeneration. Here CSF lymphocyte subpopulations and antibodies, potential players of neurodegeneration, are examined in relation to CSF NFL shedding in MS . Methods Cerebrospinal fluid NFL from 127 consecutive untreated MS patients was analysed. Samples from 37 age‐matched patients with other central nervous...