Background and aims: In a previous study, we had detected perturbations in IFITM3 networks in both the CNS and peripheral immune cells donated by AD patients.The purpose of this study is to explore the transcriptomic evidence of the SARS-CoV-2-AD interplay by exploring perturbations in FYN and IFITM3 gene expression. Methods: Exploratory analyses involved meta-analysis of bulk and single cell RNA data for IFITM3 and FYN differential expression. For confirmatory analyses, we performed gene set en...
Last. Yi-Chun Kuan(TMU: Taipei Medical University)H-Index: 2
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BACKGROUND Sialorrhea often happens in patients with neurologic disorders, and botulinum toxin (BoNT) which inhibits acetylcholine activating may be an effective treatment for drooling. This systematic review and meta-analysis of randomized control trials (RCTs) aim to evaluate the efficacy and safety of BoNT in adults and children with sialorrhea due to neurological disorders. METHODS The PubMed, Embase and Cochrane databases were searched for relevant studies published before August 2021. The ...
Last. Lars Alfredsson(KI: Karolinska Institutet)H-Index: 129
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BACKGROUND Among multiple sclerosis (MS) patients, an association has been observed between low levels of vitamin D and high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels. However, whether sun exposure/vitamin D moderates the role of Epstein-Barr virus (EBV) infection in MS etiology is unclear. We aimed to investigate potential synergistic effects between low sun exposure and elevated EBNA-1 antibody levels regarding MS risk. METHODS We used a population-based case-control study involv...
The world has been kept in suspense since early 2020 by Coronavirus Disease 2019 (COVID-19), a multi-organ disease caused by the highly contagious severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Cephalalgia, the most frequent early symptom of COVID-19, is not only painful but is a disabling condition imposing substantial personal suffering, impaired quality of life, and economic burden (1). Headache in acute viral illness is seen as a consequence of the immune response, wherea...
Last. Ludwig Kappos(University of Basel)H-Index: 119
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BACKGROUND Studies reporting baseline determinants of cognitive performance and treatment effect on cognition in patients with MS are limited. We investigated the baseline correlates of cognition and the long-term treatment effects with fingolimod 0.5 mg once daily on cognitive processing speed (CPS) and attention in patients with relapsing-remitting MS (RRMS). METHODS This post-hoc analysis pooled data from the phase 3 FREEDOMS and FREEDOMS II trials (N=1556). We assessed the correlation betwee...
BACKGROUND AND PURPOSE Nitrous oxide misuse is a recognized issue worldwide. Prolonged misuse inactivates vitamin B12, causing a myeloneuropathy. METHODS Twenty patients presenting between 2016 and 2020 to tertiary hospitals in Sydney with myeloneuropathy due to nitrous oxide misuse were reviewed. RESULTS The average age was 24 years, and mean canister consumption was 148 per day for 9 months. At presentation, paresthesias and gait unsteadiness were common, and seven patients were bedbound. Mean...
#2Iris E Verhagen(Erasmus University Medical Center)H-Index: 1
Last. Gisela M. Terwindt(LUMC: Leiden University Medical Center)H-Index: 36
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BACKGROUND AND PURPOSE New prophylactics for migraine, targeting calcitonin gene-related peptide (CGRP), have recently emerged. Real-world data are important for a comprehensive understanding of treatment response. We assessed the consistency of response to erenumab, a monoclonal CGRP receptor antibody, in a real-world setting, in order to determine which patients may be considered responders in clinical practice. METHODS All erenumab-treated patients (n = 100) completed a time-locked daily elec...
BACKGROUND AND PURPOSE Arterial clot localization affects collateral flow to ischemic brain in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). We determined the association between vessel occlusion locations, tissue-level collaterals (TLC), and venous outflow (VO) profiles and their impact on good functional outcomes. METHODS We conducted a multicenter retrospective cohort study of consecutive AIS-LVO patients who underwent thrombectomy triage. Baseline computed tomo...
#1Rob Molenberg(UMCG: University Medical Center Groningen)H-Index: 3
#2Marlien W. Aalbers(UMCG: University Medical Center Groningen)H-Index: 11
Last. J. Marc C. van Dijk(UMCG: University Medical Center Groningen)H-Index: 22
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BACKGROUND AND PURPOSE Aneurysm wall enhancement (AWE) of intracranial aneurysms on magnetic resonance imaging has been described in previous studies as a surrogate marker of instability. With this study, an updated literature overview and summary risk estimates of the association between AWE and different specific outcomes (i.e., rupture, growth or symptomatic presentation) for both cross-sectional and longitudinal studies are provided. METHODS The PRISMA guideline was followed and a search was...
We read with interest the letter from Gasparini et al, in which the authors highlight the selection & classification biases in our recent study (1). We are aware of these biases, and we addressed them in the paper's discussion. When considering selection bias, we clearly stated in the discussion that the 35 CMT patients were the most obvious candidates for CMT genetic investigation and that less obvious patients are probably still included in the initial cohort of 1104 patients. As detailed in t...