Original paper
FAK-heterozygous mice display enhanced tumour angiogenesis
Abstract
Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced stromal FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T tumour growth and angiogenesis. We further demonstrate that cell proliferation and microvessel sprouting, but not migration, are increased in...
Paper Details
Title
FAK-heterozygous mice display enhanced tumour angiogenesis
Published Date
Jun 25, 2013
Journal
Volume
4
Issue
1
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Notes
History