TRP-channel-specific cutaneous eicosanoid release patterns

Summary Specific transient receptor potential channel agonists induced a differential release pattern of LTB4 and PGE2 from skin. These might directly influence perception thresholds and neurogenic inflammatory symptoms. Analyzing mechanisms and key players in peripheral nociception nonneuronal skin cells are getting more and more into focus. Herein we investigated the functional expression of TRPV1 and TRPA1 in human keratinocytes and...