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#1Beatrice Korwisi (CU: Catholic University of Eichstätt-Ingolstadt)H-Index: 1
#2Antonia BarkeH-Index: 23
Last. Maria KleinstäuberH-Index: 18
view all 5 authors...
ABSTRACT The upcoming 11th revision of the International Classification of Diseases (ICD-11) will include a comprehensive classification of chronic pain for the first time, which is based on the biopsychosocial definition of chronic pain. This presents a great opportunity for pain research and clinical practice. The new classification consists of seven main diagnostic categories of chronic pain, which are further divided into increasingly specific levels of diagnoses. Each diagnosis is character...
#1Francesca Guida (Seconda Università degli Studi di Napoli)H-Index: 27
#2Monica IannottaH-Index: 11
Last. Sabatino MaioneH-Index: 49
view all 15 authors...
ABSTRACT Neuropathic pain has long-term consequences in terms of affective and cognitive disturbances suggesting the involvement of supraspinal mechanisms. In the present study, we used the spared nerve injury (SNI) model to characterize the development of sensory and aversive components of neuropathic pain, and to determine their electrophysiological impact across PFC and limbic regions. Moreover, we evaluated the regulation of several genes involved in immune response and inflammation triggere...
#1David Schelly (Clarkson University)H-Index: 6
#1Laura SirucekH-Index: 3
#2R. C. PriceH-Index: 3
Last. Petra SchweinhardtH-Index: 35
view all 8 authors...
Endogenous opioids mediate the pleasurable responses to positively reinforcing stimuli such as palatable food. Yet, the reduction or omission of a negative experience can also be rewarding (negative reinforcement). As such, pain relief leads to negative reinforcement and evokes a pleasant feeling in humans. Although it has been shown that the feeling of pleasure associated with positive reinforcement is at least partly mediated through endogenous opioids, it is currently unknown whether similar ...
#1Amit Jain (Cleveland Clinic)H-Index: 9
Last. Massimo LampertiH-Index: 15
view all 4 authors...
#1Lynn S. WalkerH-Index: 49
#2Amanda L. StoneH-Index: 11
Last. Tonya M. PalermoH-Index: 55
view all 8 authors...
ABSTRACT Inconsistent results of psychological treatments for pediatric functional abdominal pain (FAP) may be due to heterogeneity of patients' pain-related psychological characteristics. This randomized controlled trial tested whether statistically derived patient subgroups (high pain dysfunctional [HPD], high pain adaptive [HPA], and low pain adaptive [LPA]) moderated response to cognitive behavior therapy (CBT) for adolescents with FAP and their parents (n = 278 dyads; patients were 66% fema...
#1Jeffrey F. ScherrerH-Index: 45
#2Joanne SalasH-Index: 17
Last. Brian K. AhmedaniH-Index: 26
view all 9 authors...
ABSTRACT Long-term opioid therapy (LTOT) is associated with increased risk for depression. It is not known if the frequency of opioid use during LTOT is associated with new onset depression. We used Optum's de-identified Integrated Claims-Clinical dataset (2010-2018) to create a cohort of 5,146 patients, 18 - 80 years of age with an encounter or claims in the year before new LTOT. New LTOT was defined by > 90 day opioid use after remaining 6-months opioid free. Opioid use frequency during the fi...
#1Sena Chung (UPRRP College of Natural Sciences)
Last. Seog Bae OhH-Index: 37
view all 6 authors...
ABSTRACT Nociceptors are known to directly recognize bacterial cell wall components or secreted toxins, thereby leading to pain induced by bacterial infection. However, direct activation of nociceptors by bacterial metabolites remains unclear even though bacteria produce numerous metabolites related to health and disease. In the current study, we investigated whether and how a common bacterial metabolite, indole, which is produced by normal microflora of the gastrointestinal (GI) tract and oral ...
#1Caitlin B. Murray (CCHMC: Cincinnati Children's Hospital Medical Center)
#2Rocío de la VegaH-Index: 15
Last. Tonya M. PalermoH-Index: 55
view all 5 authors...
ABSTRACT Prior systematic reviews have summarized the prevalence and impact of chronic pain in "average" pediatric (i.e., school-age) and adult (i.e., middle-age) age groups. To our knowledge, this is the first study to describe the prevalence of chronic pain in the subgroup of individuals that fall in between established boundaries of "childhood" and "adulthood" - known as young adulthood. The goal of this research was to meta-analyze prevalence data on pain in young adults based on available d...
#1Margherita Marchi (UNIMI: University of Milan)
#2Ilaria D'AmatoH-Index: 3
Last. Giuseppe LauriaH-Index: 41
view all 8 authors...
ABSTRACT Mutations in the alpha subunit of voltage-gated sodium channel 1.7 (NaV1.7), encoded by SCN9A gene, play an important role in the regulation of nociception, and can lead to a wide range of clinical outcomes, ranging from extreme pain syndromes to congenital inability to experience pain. To expand the phenotypic and genotypic spectrum of SCN9A-related channelopathies we describe the proband, a daughter born from consanguineous parents, that had pain insensitivity, diminished temperature ...
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