Acid-sensing ion channels in pain and disease

Acid-sensing ion channels (ASICs) have been implicated in pain, and neurological and psychiatric disease. Wemmieet al. provide an update on the roles of ASICs in health and disease, and consider the implications for therapy and future lines of research. Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the...