Autocrine-regulated airway smooth muscle cell migration is dependent on IL-17–induced growth-related oncogenes

BackgroundAirway smooth muscle cell (ASMC) migration is one of the proposed mechanisms underlying the increased airway smooth muscle mass seen in airway remodeling of patients with severe asthma. IL-17–related cytokines are a new subgroup of inflammatory mediators that have been suggested to play a role in regulating smooth muscle function. We hypothesized that IL-17–induced chemokine production from smooth muscle cells can contribute to...