Licochalcone A: A lipase inhibitor from the roots of Glycyrrhiza uralensis

In order to develop a functional food and anti-obesity drug through the inhibition of absorption of dietary lipids, we investigated the inhibitory effects on pancreatic lipase of extracts from more than 800 species of herbs in Korea. In this study, licochalcone A was isolated from the ethyl acetate/n-hexane fraction of ethyl acetate extract of the roots of Glycyrrhiza uralensis. Its structure was elucidated by 1H NMR, 13C NMR and HR-EI mass...