Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
Abstract
High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour suppressor p53 is a primary factor inducing death of crypt cells with DNA damage, its essential role in maintaining genome stability means inhibiting p53 to prevent GIS is not a viable strategy. Here we show that the innate immune receptor Toll-like receptor 3 (TLR3) is...
Paper Details
Title
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
Published Date
Mar 18, 2014
Journal
Volume
5
Issue
1
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