Original paper
Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity
Abstract
Interleukin-12 (IL-12) is a heterodimeric cytokine that enhances immune responses to bacterial, parasitic, and viral pathogens, and leads to tumor regression in animal models. For this reason, the use of IL-12 as a vaccine adjuvant and as a therapeutic agent for the treatment of cancer is being investigated. Unfortunately, the extreme toxicity of this molecule observed during clinical trials has limited its use. This toxicity correlates with...
Paper Details
Title
Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity
Published Date
Jun 1, 2003
Volume
3
Issue
6
Pages
801 - 809
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Notes
History