Coordinated Messenger RNA/MicroRNA Changes in Fibroblasts of Patients with Major Depression

Peripheral biomarkers for major psychiatric disorders have been an elusive target for the last half a century. Dermal fibroblasts are a simple, relevant, and much underutilized model for studying molecular processes of patients with affective disorders, as they share considerable similarity of signal transduction with neuronal tissue.Cultured dermal fibroblast samples from patients with major depressive disorder (MDD) and matched control...