Topical Loteprednol Pretreatment Reduces Cyclosporine Stinging in Chronic Dry Eye Disease

Published on Feb 19, 2011in Journal of Ocular Pharmacology and Therapeutics1.925
· DOI :10.1089/JOP.2010.0085
John D. Sheppard21
Estimated H-index: 21
(EVMS: Eastern Virginia Medical School),
Stephen V. Scoper3
Estimated H-index: 3
Sandeep S. Samudre7
Estimated H-index: 7
Abstract Purpose: This retrospective, clinical comparative analysis describes differences in clinical signs and symptoms and medication tolerability between those patients who receive topical corticosteroids prior to initiation of topical cyclosporine 0.5% emulsion (tCSA) therapy for chronic dry eye disease (CDED) and those who received tCSA and were not first induced with corticosteroid drops. tCSA is the only approved medication for CDED. Stinging is the most common side effect of tCSA and reason for tCSA discontinuation. This analysis describes an effective pharmacologic means to reduce tCSA stinging and subsequent discontinuation. Methods: Thirty-six consecutive patients were initially treated with loteprednol etabonate (LE) 0.5% (Lotemax; Bausch & Lomb) for a period ranging from 2 to 16 months prior to institution of concomitant tCSA (Restasis™; Allergan). Clinical parameters (fluorescein staining, conjunctival redness, tear meniscus) were compared over a period of 6 months to a second cohort of 36 c...
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