Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats

The pathophysiology of non‑alcoholic fatty liver disease remains to be elucidated, and the currently available treatments are not entirely effective. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspi­datum, has previously been demonstrated to possess hepatoprotective effects. The present study aimed to determine the effects of polydatin supplementation on hepatic fat accumulation and injury in rats fed a high‑fat diet....