Molecular Medicine Reports
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#1So Eun Kim (CBNU: Jeonbuk National University)H-Index: 1
#2Ha-Young Shin (CBNU: Jeonbuk National University)
Last. Jae Chol Yoon (CBNU: Jeonbuk National University)H-Index: 1
view all 14 authors...
Although multi‑organ dysfunction is associated with the survival rate following cardiac arrest (CA), the majority of studies to date have focused on hearts and brains, and few studies have considered renal failure. The objective of the present study, therefore, was to examine the effects of therapeutic hypothermia on the survival rate, pathophysiology and antioxidant enzymes in rat kidneys following asphyxial CA. Rats were sacrificed one day following CA. The survival rate, which was estimated u...
#1Kaifeng Gan (NBU: Ningbo University)H-Index: 3
#2Wei Wu (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Jin Li (NBU: Ningbo University)H-Index: 1
view all 8 authors...
Numerous studies have previously demonstrated that long non‑coding RNAs (lncRNAs) serve an important regulatory role in osteoarthritis (OA). In particular, the lncRNA family with sequence similarity 201 member A (FAM201A) was previously found to be downregulated in necrotic femoral head samples. However, the role of FAM201A in IL‑1β‑induced chondrocyte injury remains unclear. It was hypothesized that FAM201A may exert a protective effect on IL‑1β‑induced chondrocyte injury in OA by sponging micr...
#1Yinxian Wen (WHU: Wuhan University)H-Index: 7
#2Siyuan Cheng (WHU: Wuhan University)H-Index: 2
Last. Hui Wang (WHU: Wuhan University)H-Index: 87
view all 7 authors...
Prenatal food restriction (PFR) induces dysfunction of the hypothalamic‑pituitary‑adrenal (HPA) axis in the adult offspring. The aim of the present study was to identify the underlying mechanism of this process. Pregnant rats were placed on a restricted diet between gestational day 11 and 21. The offspring were fed with a high‑fat diet and were subjected to unpredictable chronic stress (UCS) from postnatal week 17 to 20. A higher serum corticosterone (CORT) level was observed in the PFR fetuses....
#1Li Linjin (WMC: Wenzhou Medical University)H-Index: 2
#2Hu Yiren (WMC: Wenzhou Medical University)
Last. Rui Feng
view all 9 authors...
Prostate cancer (PCa) endangers the life and health of older men. Most PCa cases develop into castration‑resistant PCa (CRPC) within 2 years. At present, the molecular mechanisms of the occurrence and development of PCa and its transformation to CRPC remain unknown. The present study aimed to investigate the role of CKLF‑like Marvel transmembrane domain containing family member 5 (CMTM5) in PCa and its molecular mechanism in vitro. PCa tissues and paired adjacent normal prostate tissues from 70 ...
#1Jian WangH-Index: 8
#2Wu XiaochenH-Index: 3
Last. Jinbao ZhangH-Index: 3
view all 10 authors...
Angina pectoris is cardiac pain that is a common clinical symptom often resulting from myocardial ischemia. Spinal cord stimulation (SCS) is effective in treating refractory angina pectoris, but its underlying mechanisms have not been fully elucidated. The spinal dorsal horn is the first region of the central nervous system that receives nociceptive information; it is also the target of SCS. In the spinal cord, glial (astrocytes and microglia) activation is involved in the initiation and persist...
#1Jian Shi (HMU: Hebei Medical University)H-Index: 1
#2Jingtian Wang (HMU: Hebei Medical University)H-Index: 1
Last. Yan Zhao (HMU: Hebei Medical University)H-Index: 2
view all 9 authors...
Forkhead box (FOX) proteins are multifaceted transcription factors that have been shown to be involved in cell cycle progression, proliferation and metastasis. FOXP4, a member of the FOX family, has been implicated in diverse biological processes in tumor initiation and progression. However, the molecular mechanisms of FOXP4 in laryngeal squamous cell carcinoma (LSCC) remain unknown. In the present study, differentially expressed transcripts in transforming growth factor‑β‑treated TU177 cells we...
#1Yali Zhang (XJTU: Xi'an Jiaotong University)H-Index: 18
#2Mahreen Fatima (XJTU: Xi'an Jiaotong University)
Last. Enqi Liu (XJTU: Xi'an Jiaotong University)H-Index: 24
view all 6 authors...
Atherosclerosis is a chronic inflammatory disease that threatens human health and lives by causing vascular stenosis and plaque rupture. Various animal models have been employed for elucidating the pathogenesis, drug development and treatment validation studies for atherosclerosis. To the best of our knowledge, the species used for atherosclerosis research include mice, rats, hamsters, rabbits, pigs, dogs, non‑human primates and birds, among which the most commonly used ones are mice and rabbits...
The global morbidity rate of preeclampsia (PE) is 3‑7, and 10‑20% of maternal deaths are associated with PE. However, the mechanism of its pathogenesis remains unknown. The aim of the present study was to examine the relationship between microRNA‑302a (miR‑302a) and PE. Firstly, the relative expression levels of miR‑302a in placental tissues from patients with PE and normal controls were analyzed using reverse transcription‑quantitative PCR. miR‑302a expression was upregulated in PE tissues, par...
#1Anna LiH-Index: 1
#2Shuxian LiH-Index: 2
Last. Meihua ZhangH-Index: 1
view all 8 authors...
Recurrent spontaneous abortion (RSA) effects both the physical and mental health of women of reproductive age. Trophoblast dysfunction may result in RSA due to shallow placental implantation. The mechanisms underlying formyl peptide receptor 2 (FPR2) on the biological functions of trophoblasts remain to be elucidated. The present study aimed to explore the potential functions of FPR2, a G protein‑coupled receptor, in placental trophoblasts. The location and expression levels of FPR2 in the villi...
#1Mingyang Li (HMU: Harbin Medical University)
#2Licheng Cai (HMU: Harbin Medical University)H-Index: 4
Last. Chun-sheng Li (Chifeng University)H-Index: 1
view all 11 authors...
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with a poor prognosis and high mortality rate. The increasing incidence of RCC poses a serious threat to human health. It is well‑documented that rhomboid domain‑containing protein 1 (RHBDD1) plays a vital role in cancer progression. The present study was designed to identify the biological functions of RHBDD1 in RCC and investigate the underlying regulatory mechanism, aiming to explore the novel molecular therapeutic t...
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