Molecular Medicine Reports
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#1Wei Zhao (Guida: Guizhou University)H-Index: 1
#2Li Chen (Guida: Guizhou University)
Last. Shanshan Li (Guida: Guizhou University)
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The present study aimed to investigate the protective effect of carvacrol on liver injury in mice with type 2 diabetes mellitus (T2DM) and to assess its potential molecular mechanism. Mice were divided into three groups (n=15/group): Non‑diabetic db/m+ mice group, db/db mice group and db/db mice + carvacrol group. In the db/db mice + carvacrol group, db/db mice were administered 10 mg/kg carvacrol daily by gavage for 6 weeks. Fasting blood glucose and insulin levels were separately examined. Pat...
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#1Sixiang Li (Sichuan University)
#2Shuang Zhao (Sichuan University)
Last. Weimin Li (Sichuan University)H-Index: 24
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Inflammation serves a key role in chronic obstructive pulmonary disease (COPD). However, changes in the immune profiles of patients with COPD remain unclear. The present prospective observational study aimed to determine the expression profiles of immune cells and inflammatory factors of patients with COPD and healthy controls, and to analyze the relationship between immune profiles and smoking history. A total of 140 subjects were enrolled in the present study between September 2018 and April 2...
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#2Xuefeng Zhou (Nantong University)H-Index: 1
Last. Dongyun Gao (Nantong University)
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Lung cancer is one of the most prevalent cancers in China, and its incidence and morbidity remain high due to various independent factors. Lung adenocarcinoma (ADC) is the most common type of non‑small cell lung carcinoma. Circular RNA plasmacytoma variant translocation 1 (circ‑PVT1) plays an oncogenic role in various types of cancer, but the specific role of circ‑PVT1 in lung ADC has not yet been reported. In the present study, circ‑PVT1 was knocked down in A549 cells and the cell viability, pr...
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#1Hui Li (Nanjing University of Chinese Medicine)H-Index: 1
#2Wen Cao (Nanjing University of Chinese Medicine)
Last. Min Lu
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Diabetic gastroparesis (DGP), also known as delayed gastric emptying, is a common complication of diabetes mellitus. There are numerous clinical symptoms associated with DGP, as well as high treatment costs and markedly reduced patient quality of life. However, the pathogenesis of DGP is not clear, thus effective treatment methods are yet to be established. In the present study, a DGP rat model was established in Sprague‑Dawley rats by the intraperitoneal injection of streptozotocin (STZ). DGP m...
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#1Dong-dong Li (SHU: Shanghai University)
#2Luobing Wang (SHU: Shanghai University)
Last. Jian-dong Gao (SHU: Shanghai University)
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Increasing uric acid (UA) could induce renal tubular epithelial cell (NRK‑52E) injury. However, the specific mechanism by which UA induces renal tubular epithelial cell injury remains unknown. It was hypothesized that UA induces renal tubular epithelial cell injury through reactive oxygen species (ROS) and the Never in mitosis gene A (NIMA)‑related kinase 7 (NEK7)/NLR family pyrin domain containing 3 (NLRP3) signaling pathway. TUNEL assay and flow cytometry were applied to measure apoptosis, and...
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#1Tianchi Yu (Nanjing Medical University)
#2Tao Wang (Nanjing Medical University)
Last. Hui Zhang (Nanjing Medical University)
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Vascular smooth muscle cells (VSMCs) serve a decisive role in intimal hyperplasia, a common pathophysiological process that leads to numerous vascular disorders. The present study aimed to investigate the unknown mechanisms underlying VSMC phenotypic modulation and identified a novel microRNA (miRNA/miR)‑17‑5p/homeobox B13 (HOXB13) axis involved in the phenotypic switching, proliferation and migration of VSMCs. VSMCs were isolated from the thoracic aorta of Sprague‑Dawley rats, cell proliferatio...
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#1Li-Hong ZhaoH-Index: 1
#2Hong ZhengH-Index: 1
Last. Ping JiangH-Index: 5
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To investigate the changes of circular (circ)RNA circCD151 expression in lung cancer tissues and cells and its effects on proliferation, migration and invasion of lung cancer cells. The relative expression levels of circCD151 in lung cancer tissues and lung cancer cells (A549 and NCI‑H292) were determined by reverse transcription‑quantitative PCR. The effects of silencing or upregulation of circCD151 on the activity and clonal forming ability of A549 and NCI‑H292 cells were detected by CCK‑8 and...
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#1Hongwei Shi (HUST: Huazhong University of Science and Technology)
#2Qingfu Zeng (WHU: Wuhan University)
Last. Rui Feng (CQMU: Chongqing Medical University)
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Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various types of cancer, but its cardiotoxicity cannot be ignored. Canagliflozin, the first sodium‑glucose co‑transporter‑2 inhibitor approved by the USA FDA, has been shown to have a significant effect on cardiovascular damage caused by diabetes. However, it has not been reported whether it can resist THP‑induced cardiotoxicity. The aim of the present study was to investigate the effect of canaglifl...
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#1Qingchun Lei (Kunming Medical University)
#2Tingting Wu (Kunming Medical University)
Last. Guolin Shi (Kunming Medical University)
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Parkinson's disease (PD) is the second most common neurodegenerative disease amongst the middle‑aged and elderly populations. Several studies have confirmed that the microbiota‑gut‑brain axis (MGBA) serves a key role in the pathogenesis of PD. Changes to the gastrointestinal microbiome (GM) cause misfolding and abnormal aggregation of α‑synuclein (α‑syn) in the intestine. Abnormal α‑syn is not eliminated via physiological mechanisms and is transported into the central nervous system (CNS) via th...
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#1Juanjuan Qiu (Dalian Medical University)H-Index: 2
#2Xiaoguang Xiao (Dalian Medical University)
Last. Yongli Zhang (Dalian Medical University)
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Myocardial injury is the primary manifestation of multiple organ dysfunction during sepsis, however, the mechanisms underlying sepsis‑induced myocardial injury remain unclear. Similarly, no effective therapeutics have yet been developed for myocardial injury. In the present study, the role of the NOD‑like receptor 3 (NLRP3) inflammasome on cardiac function were characterized and the effects of different ulinastatin (UTI) doses in protecting a septic rat model from myocardial injury were elucidat...
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