Molecular Medicine Reports
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#1Hongmei Ding (Soochow University (Suzhou))
#2Hong Zhang (Soochow University (Suzhou))H-Index: 4
Last. Youguo Chen (Soochow University (Suzhou))H-Index: 7
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#1Ying Xuan (PRC: China Medical University (PRC))
#2Shuang Zhao (PRC: China Medical University (PRC))H-Index: 1
Last. Hua-Chuan Zheng (PRC: China Medical University (PRC))
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Chaperone‑mediated autophagy (CMA) is a selective type of autophagy whereby a specific subset of intracellular proteins is targeted to the lysosome for degradation. The present study investigated the mechanisms underlying the response and resistance to 5‑fluorouracil (5‑FU) in colorectal cancer (CRC) cell lines. In engineered 5‑FU‑resistant CRC cell lines, a significant elevation of lysosome‑associated membrane protein 2A (LAMP2A), which is the key molecule in the CMA pathway, was identified. Hig...
#1Mengmeng Xia (YZU: Yangzhou University)H-Index: 2
#2Jing Xia (YZU: Yangzhou University)H-Index: 3
Last. Ying Zheng (YZU: Yangzhou University)H-Index: 8
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#1Zengpeng Sun (Hunan Normal University)H-Index: 1
#2Zhiguo Tan (Hunan Normal University)
Last. Weimin Yi (Hunan Normal University)H-Index: 3
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Circular RNAs (circRNAs) are a class of non‑coding RNAs formed by covalently closed loops through back‑splicing and exon‑skipping. circRNAs have been confirmed to play a vital role in various biological functions, acting as microRNA sponges and reservoirs, as well as combining with RNA‑binding proteins during the progression of multiple cancer types. Therefore, the present review evaluated recent research articles in PubMed that were published between November 2017 and September 2020. Key word s...
#1Songbo Fu (Lanzhou University)H-Index: 1
Last. Jizu Ling (Lanzhou University)
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#1Yan Wen (SYSU: Sun Yat-sen University)
#2Yao Chun (SYSU: Sun Yat-sen University)
Last. Zhang Huan Ji (SYSU: Sun Yat-sen University)
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Atherosclerosis (AS) is a chronic inflammatory disease of the vascular wall with multiple causes. AS is the primary pathological basis of cardiovascular disease and stroke. Moreover, carotid plaque rupture and thrombus formation are the main causes of ischemic stroke. Therefore, understanding the formation of carotid plaques may help improve the prediction and prevention of cardiovascular and cerebrovascular events. Endothelial cell dysfunction results in re‑endothelialization and angiogenesis i...
#1Zhengzheng Xiao (HAUST: Henan University of Science and Technology)
#2Xiaoli Yang (HAUST: Henan University of Science and Technology)
Last. Zhengwei Li (WHU: Wuhan University)
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Recent studies have reported that gene amplified in squamous cell carcinoma 1 (GASC1) is involved in the progression of several types of cancer. However, whether GASC1 promotes glioma progression remains unknown. Therefore, the present study aimed to investigate the effect of GASC1 exposure on glioma tumorigenesis. The western blot demonstrated that grade III and IV glioma tissues exhibited a higher mRNA and protein expression of GASC1. Moreover, CD133+ U87 or U251 cells from magnetic cell separ...
#1Libo Zhu (ZJU: Zhejiang University)
#2Zhuqing Liu (ZJU: Zhejiang University)
Top fields of study
Molecular biology
Cell cycle
Cancer research
Molecular medicine