Molecular Medicine Reports
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Last. Liang Dong (ZJU: Zhejiang University)
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Atherosclerosis is a primary cause of multiple types of cardiovascular disease, including myocardial infarction. In addition, injury of human umbilical vein endothelial cells (HUVECs) can lead to the development of atherosclerosis. Circular (circ)RNAs participate in atherosclerosis. It has previously been shown that circRNA cSMARCA5 (hsa_circ_0001445) expression is downregulated in atherosclerosis. However, the effects of hsa_circ_0001445 on the proliferation of HUVECs remain unclear. In order t...
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#1Zengpeng Sun (Hunan Normal University)H-Index: 1
#2Zhiguo Tan (Hunan Normal University)
Last. Weimin Yi (Hunan Normal University)H-Index: 3
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Glycyrrhizin (GA) is the most essential active ingredient in licorice root, and has a wide range of biological and pharmacological activities. The present study aimed to conduct a detailed analysis of the effects of GA on liver cancer (LC) cell proliferation and the Warburg effect. Hexokinase‑2 (HK2) is a glycolytic enzyme that catalyzes the Warburg effect. To this end, the LC HepG2 cell line was transfected with small interfering RNA‑HK2 or pCDNA3.1‑HK2, followed by GA treatment. A Cell Countin...
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#1Liyan BoH-Index: 7
#2Yanyan Li (Fourth Military Medical University)H-Index: 7
Last. Congcong LiH-Index: 6
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Localization of phosphorylated (p)‑JNK to the mitochondria can lead to functional mitochondrial disorder, resulting in a decrease in energy supply and membrane potential, as well as an increase in reactive oxygen species production and apoptosis. JNK is involved in the occurrence of acute lung injury (ALI), and activation of the JNK pathway is one of the crucial factors resulting in injury. The aim of the present study was to investigate whether the JNK‑mitochondria (mitoJNK) location participat...
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#1Hui Wang (Zunyi Medical College)
#2Jiaxing An (Zunyi Medical College)H-Index: 3
Last. Biguang Tuo (Zunyi Medical College)H-Index: 21
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Cl‑/HCO3‑ anion exchangers (AEs), which are members of the solute carrier 4 family, contribute to the exchange of one intracellular HCO3‑ for one extracellular Cl‑. AE2, a vital subtype of the Cl‑/HCO3‑ exchangers, is expressed widely in various cells and tissues in mammals and serves essential roles in the pathophysiological processes of the cardiovascular system and renal tubular reabsorption. Recently, research on the function of AE2 in the digestive system shed new light on its roles in the ...
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#1Xiaofu Song (PRC: China Medical University (PRC))
#2Zhiqiang Cui (PRC: China Medical University (PRC))
Last. Xiaohong Sun (PRC: China Medical University (PRC))
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Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder with slow onset in most cases. Clinically, dementia associated with AD is characterized by memory disorders, aphasia, executive dysfunction and personality and behavior changes. Currently, treatment strategies attempt to reduce certain symptoms, however there is no cure for AD. The aim of the present study was to identify a novel treatment strategy for AD. Thus, the protective effects of a κ‑opioid receptor (KOR) agonist,...
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#1Dong Young Kang (Konkuk University)H-Index: 11
#2Nipin Sp (Konkuk University)H-Index: 10
Last. Young Mok Yang (Konkuk University)H-Index: 22
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Janus kinase 2 (JAK2) and STAT3 signaling is considered a major pathway in lipopolysaccharide (LPS)‑induced inflammation. Toll‑like receptor 4 (TLR‑4) is an inflammatory response receptor that activates JAK2 during inflammation. STAT3 is a transcription factor for the pro‑inflammatory cytokine IL‑6 in inflammation. Sulfur is an essential element in the amino acids and is required for growth and development. Non‑toxic sulfur (NTS) can be used in livestock feeds as it lacks toxicity. The present s...
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#2Yaoqi Wang (Tianjin Medical University General Hospital)H-Index: 5
Last. Hongguang Chen (Tianjin Medical University General Hospital)
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Renal ischemia/reperfusion (I/R) injury can lead to acute renal failure, delayed graft function and graft rejection. Nucleotide‑binding oligomerization domain NOD‑like receptor containing pyrin domain 3 (NLRP3)‑mediated inflammation participates in the development of renal injury. Nrf2 accelerates NLRP3 signaling pathway activation and further regulates the inflammatory response. In addition, hydrogen sulfide serves a protective role in renal injury; however, the detailed underlying mechanism re...
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Sepsis is a syndrome characterized by organ dysfunction and an abnormal immune response to infection. A growing body of research has shown the importance of long non‑coding RNAs (lncRNAs) in tumorigenesis, virus replication, inflammatory injury and other pathological processes. The aim of the present study was to explore the role and potential mechanism of the lncRNA growth arrest‑specific 5 (GAS5) in the lipopolysaccharide (LPS)‑induced inflammation and apoptosis of THP‑1 cells. An in vitro sep...
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#1Song TianH-Index: 4
#2Yongjun ZhengH-Index: 8
Last. Zhaofan XiaH-Index: 1
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A hypertrophic scar (HPS) is characterized by abnormal cell proliferation and the overproduction of extracellular matrix. Currently, the treatment options available for this remain unsatisfactory. Innovative treatments are required to attenuate or prevent hypertrophic scarring and the present study searched for a drug capable of becoming a new preventative and therapeutic strategy. Although the underlying mechanisms have not been fully clarified; it is widely accepted that the TGF‑β1/SMAD3 signa...
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#1Bo Liu (Hunan University)H-Index: 1
#2Yuan Tang (Hunan University)H-Index: 1
Last. Jinwen Ge (Hunan University)H-Index: 6
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The present study sought to elucidate the role of Polygonatum sibiricum F. Delaroche polysaccharide (PSP) in high‑fat diet (HFD)‑induced mouse obesity and investigated the primary molecular mechanism underlaying these effects. An obese mouse model was established by feeding HFD and three doses of PSP were administered intragastrically. Changes in body weight, serum lipids and parameters were recorded and the mechanism was explored by reverse transcription‑quantitative PCR and western blotting. B...
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