Fabrication of hollow hydroxyapatite particles assisted by small organic molecule and effect of microstructure on protein adsorption

Nanostructured hollow hydroxyapatite (HA) particles were fabricated under hydrothermal conditions with cyclohexane-1,2,3,4,5,6-hexacarboxylic acid (H 6 L) as the template, and their formation process was investigated. Without the assistance of H 6 L, the product consisted of ribbon-like HA crystals. With the introduction of H 6 L, the HA particles gradually changed from flower-like plate aggregates to microspheres. Nanostructured hollow HA...