Review paper
The anticoagulant function of coagulation factor V
Abstract
Summary Almost two decades ago an anticoagulant function of factor V (FV) was discovered, as an anticoagulant cofactor for activated protein C (APC). A natural mutant of FV in which the R506 inactivation site was mutated to Gln (FVLeiden) was inactivated slower by APC, but also could not function as anticoagulant cofactor for APC in the inactivation of activated factor VIII (FVIIIa). This mutation is prevalent in populations of Caucasian...
Paper Details
Title
The anticoagulant function of coagulation factor V
Published Date
Jan 1, 2012
Journal
Volume
107
Issue
01
Pages
15 - 21
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History