Role of TRPC1 channel in skeletal muscle function

Skeletal muscle contraction is reputed not to depend on extracellular Ca 2+ . Indeed, stricto sensu , excitation-contraction coupling does not necessitate entry of Ca 2+ . However, we previously observed that, during sustained activity (repeated contractions), entry of Ca 2+ is needed to maintain force production. In the present study, we evaluated the possible involvement of the canonical transient receptor potential (TRPC)1 ion channel in this...