Levels of Maternal Serum Angiogenic Factors in Third-Trimester Normal Pregnancies: Reference Ranges, Influence of Maternal and Pregnancy Factors and Fetoplacental Doppler Indices

Published on Jan 1, 2014in Fetal Diagnosis and Therapy2.587
· DOI :10.1159/000360078
Silvia M. Lobmaier12
Estimated H-index: 12
(University of Barcelona),
Francesc Figueras58
Estimated H-index: 58
+ 6 AuthorsEduard Gratacós88
Estimated H-index: 88
Sources
Abstract
Aim: To establish normal ranges of maternal placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PlGF ratio at 32-41 weeks' gest
📖 Papers frequently viewed together
References32
Newest
#1Andreea G. Moore (GW: George Washington University)H-Index: 2
#2Heather A. Young (GW: George Washington University)H-Index: 25
Last. Sharon Maynard (Lehigh Valley Hospital)H-Index: 15
view all 7 authors...
Objective: To determine if maternal serum angiogenic factors predict maternal and neonatal complications in women presenting to an acute care setting with suspected preeclampsia. Study design: Maternal serum samples were prospectively collected from women with suspected preeclampsia at the time of initial presentation to hospital triage with signs or symptoms of preeclampsia. Soluble fms-like tyrosine kinase-1 (sFlt1), placental growth factor (PlGF), and soluble endoglin (sEng) were measured by ...
Source
OBJECTIVE: To estimate whether the imbalance of angiogenic factors (soluble fms-like tyrosine kinase-1, placental growth factor) and fibrinolytic factors (plasminogen activator inhibitor-2 [PAI-2]) might affect placentation in early pregnancy. METHODS: We studied the associations of maternal soluble fms-like tyrosine kinase-1, placental growth factor, and PAI-2 concentrations in the first trimester (before 18 weeks of gestation) and soluble fms-like tyrosine kinase-1 and placental growth factor ...
Source
#1Stefan Verlohren (Charité)H-Index: 31
#2Ignacio HerraizH-Index: 22
Last. Holger StepanH-Index: 48
view all 12 authors...
Objective The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders. Study Design We investigated 388 singleton pregnancies with normal pregnancy outcome, 164 with PE, 36 with gestational hypertension, and 42 with chro...
Source
Abstract Objectives To evaluate the clinical performance of a rapid point-of-care test, Triage PLGF (Alere, San Diego) in the diagnosis of preeclampsia. Study design For the reference range 2212 plasma samples were collected from 595 subjects with normotensive pregnancies, between week 17 of gestation and delivery. In the case-control part, two cohorts of women with preeclampsia (80 women) were matched for maternal age, gestational age (GA) at sampling and parity with normotensive women who deli...
Source
#1G. Vandenberghe (VUmc: VU University Medical Center)H-Index: 1
#2I. Mensink (VUmc: VU University Medical Center)H-Index: 1
Last. J. M. G. van Vugt (VUmc: VU University Medical Center)H-Index: 17
view all 6 authors...
Objective: To assess first trimester placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) as screening markers for early-onset pre-eclampsia (PE) and intra-uterine growth restriction (IUGR). Methods: PlGF concentration was retrospectively measured in first trimester serum specimens of 23 cases of early-onset PE (<34 weeks), 26 cases of IUGR (birth weight < 5th centile) and 5 controls per case. Levels were adjusted for gestational age (GA), ethnicity and smoking to ob...
Source
#2Anne Cathrine Staff (University of Oslo)H-Index: 58
Last. Rebecca Troisi (Dartmouth College)H-Index: 18
view all 7 authors...
Objective We sought to determine if maternal characteristics are associated with angiogenic profile in the first and second trimester of normotensive pregnancies.
Source
#1Mitsuko Furuya (YCU: Yokohama City University)H-Index: 25
#2Kentaro Kurasawa (Yokohama City University Medical Center)H-Index: 8
Last. Ichiro Aoki (YCU: Yokohama City University)H-Index: 37
view all 7 authors...
The placenta plays a central role in governing local circulatory system that mediates maternal condition and fetal growth. In early gestational phases, the placenta exerts properties of invasion and neovascularization for successful placentation. Extravillous invasive trophoblasts replace uterine endometrial vasculature and establish local blood pathway to obtain oxygen and nutrients from the mother. In later phases, the placenta promotes villous angiogenesis and vascular maturation that are fin...
Source
#1Sharon Maynard (GW: George Washington University)H-Index: 15
#2S. Ananth Karumanchi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 102
Summary Preeclampsia, a hypertensive disorder peculiar to pregnancy, is a systemic syndrome that appears to originate in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of phenotypic preeclampsia was largely unknown, but recent observations support the hypothesis that altered expression of placental anti-angiogenic factors are responsible for the clinical manifestations of the disease. Soluble Flt1 and soluble endoglin,...
Source
#1Anne Cathrine Staff (University of Oslo)H-Index: 58
Last. Rebecca Troisi (Dartmouth College)H-Index: 18
view all 6 authors...
Abstract Objective Alterations in maternal circulating angiogenic factors are proposed to result in hypertension and proteinuria and development of preeclampsia. The aim of this study was to explore whether preeclampsia risk factors are associated with maternal angiogenic profile in normotensive pregnancies. Study design Associations of pregnancy characteristics and maternal serum concentrations at delivery of proangiogenic placental growth factor (PlGF), antiangiogenic soluble fms-like tyrosine...
Source
#1Arun Jeyabalan (University of Pittsburgh)H-Index: 19
#2Robert W. Powers (University of Pittsburgh)H-Index: 37
Last. Roberta B. Ness (University of Pittsburgh)H-Index: 101
view all 6 authors...
BACKGROUND Cigarette smoking during pregnancy is paradoxically associated with a reduced risk ofdeveloping preeclampsia. Both smoking and preeclampsia are associated with alterations in circulating angiogenic factors. The objective of this study was to investigate the relationship between cigarette smoking and the angiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) in pregnant women with and without preeclampsia. METHODS Plasma sFlt-1, PIGF, and coti...
Source
Cited By7
Newest
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preeclampsia, both maternal and placental vascular dysfunction plays a role in the pathogenesis and can persist into the postpartum period. Potential abnormalities include impaired placentation, incomplete s...
Source
#1M.S. Quezada (Complutense University of Madrid)H-Index: 7
#2J. Rodriguez-Calvo (Complutense University of Madrid)H-Index: 2
Last. Ignacio Herraiz (Complutense University of Madrid)H-Index: 22
view all 6 authors...
OBJECTIVE: To analyze the value of the sFlt-1/PlGF ratio to estimate the time until delivery in early-onset fetal growth restriction (FGR) preserving antegrade umbilical artery (UA) flow at diagnosis. METHODS: Prospective cohort observational study in a single center of early-onset FGR cases ( /=4 weeks. RESULTS: 120 cases were included, with 116 (96.7%) live newborns and 108 (90.0%) perinatal survivors. Median and interquartile range (IQR) gestational age at diagnosis was 27.1 (25.7 - 29.4) wee...
Source
#2Barbara Dołęgowska (Pomeranian Medical University)H-Index: 22
Last. Andrzej TorbéH-Index: 11
view all 8 authors...
AbstractObjective: Aging of the placenta is associated with natural processes that impair its functions. The processes are related to both oxidative stress exacerbation and the occurrence of higher concentrations of disordered angiogenesis markers. Both these types of processes are known to play roles in the development of preeclampsia. We attempted to show that natural ageing of the placenta can be one of the cofactors contributing to the development of late-onset preeclampsia.Patients, materia...
Source
#1Emre Zafer (Adnan Menderes University)H-Index: 5
#2Selda Demircan Sezer (Adnan Menderes University)H-Index: 6
Last. Hasan Yüksel (Adnan Menderes University)H-Index: 14
view all 6 authors...
Purpose: Elevated sFlt-1 and sEng is usually a clue for impending preeclampsia and intrauterine growth restriction. Likewise, uterine artery Doppler ultrasound is being investigated for prediction of similar conditions. In this study, we aimed to explore the possible relations of these two proteins in different body compartments with uterine artery Doppler indices (UtAD) in a healthy second trimester obstetric population.Methods: Levels of sFlt-1 and sEng were measured in serum and amniotic flui...
Source
#1Nadia Berkane (French Institute of Health and Medical Research)H-Index: 13
#2Philippe Liere (French Institute of Health and Medical Research)H-Index: 34
Last. Nathalie Chabbert-Buffet (French Institute of Health and Medical Research)H-Index: 13
view all 8 authors...
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily in the placenta by conversion of androgen precursors originating from maternal and fetal adrenal glands. These processes lead to increased plasma estrogen concentrations compared with levels in nonpregnant women. Aberrant production of estrogens could play a key role in PE symptoms because they are exclusively produced...
Source
#1Verónica ParedesH-Index: 1
#2Jasson A. Espinoza-Caicedo (Facultad de Ciencias Médicas)H-Index: 1
Last. Peter Chedraui (Facultad de Ciencias Médicas)H-Index: 10
view all 6 authors...
AbstractBackground: An imbalance between anti- and angiogenic factors during early placentation is key for the development of preeclampsia. Nevertheless, the majority of studies addressing this issue relate to maternal blood and not the fetal circulation.Objective: To measure placental growth factor (PlGF), free beta human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein-A (PAPP-A) levels in the fetal circulation of near-term pregnancies complicated with severe preeclampsi...
Source
Aim: The potential of uterine artery (UA) Doppler pulsatility index (PI) and maternal serum placental growth factor (PlGF) level to predict perinatal outcome was explored in pregnancies complicated by intrauterine fetal growth restriction (IUGR) or preeclampsia (PE). Methods: This longitudinal, prospective, and case-controlled study was conducted over a period of 24 months. At-risk pregnancies involving small-for-gestational-age (SGA) fetuses, IUGR, gestational hypertension (GH), or PE were inve...
Source
#1Silvia M. LobmaierH-Index: 12
#2F. Figueras (University of Barcelona)H-Index: 36
Last. Eduard Gratacós (University of Barcelona)H-Index: 88
view all 9 authors...
Objectives To compare the value of Doppler surveillance with maternal blood angiogenic factors at diagnosis for the prediction of adverse outcome in late-pregnancy small-for-gestational-age (SGA) fetuses. Methods In a cohort of 198 SGA fetuses we evaluated the association of Doppler indices (mean uterine artery pulsatility index (UtA-PI) and cerebroplacental ratio (CPR)) and angiogenic factors (maternal serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.