Haplosufficient Genomic Androgen Receptor Signaling Is Adequate to Protect Female Mice From Induction of Polycystic Ovary Syndrome Features by Prenatal Hyperandrogenization

Polycystic ovary syndrome (PCOS) is associated with reproductive, endocrine, and metabolic abnormalities. Because hyperandrogenism is the most consistent PCOS feature, we used wild-type (WT) and androgen receptor (AR) knockout (ARKO) mice, together with a mouse model of PCOS, to investigate the contribution of genomic AR-mediated actions in the development of PCOS traits. PCOS features were induced by prenatal exposure to dihydrotestosterone...