The Factors that Influence Skin Penetration of Solutes

In this study, human skin permeation data are analysed using a number of physicochemical descriptors. It is shown that the equilibrium distribution of compounds between the stratum corneum and water (log Km) can be correlated with either water-octanol partition coefficients (log Poct) or Abraham solute descriptors. The latter reveals that partitioning of compounds is governed by solute size and hydrogen-bond acidity that favour the stratum...