Journal of Pharmacy and Pharmacology
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#1Farzana S. Bandarkar (KU: Kuwait University)H-Index: 6
#2Willias Masocha (KU: Kuwait University)H-Index: 18
Last. Aly Nada (KU: Kuwait University)H-Index: 9
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OBJECTIVES The main objective of this study was to evaluate the antinociceptive and anti-inflammatory activity of ibuprofen (IB) nanoformulations which were developed in our previous study and showed enhanced in-vitro dissolution rate compared with the marketed formulation. METHODS The in-vivo pharmacodynamic (PD) studies were performed in mice. The antinociceptive effect of the formulations was evaluated using the formalin test, whereas the anti-inflammatory activity was evaluated by measuring ...
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OBJECTIVES This study aimed to evaluate the in vitro anti-Leishmania activity of chalcone-rich three extracts (LDR, LHR and LMR) from Lonchocarpus cultratus (Vell.) A.M.G. Azevedo & H.C. Lima against L. amazonensis. Also, the immunomodulatory and antioxidant capacity was assessed. METHODS Successive extraction with hexane, dichloromethane and methanol were performed to obtain LHR, LDR and LMR extracts from L. cultratus roots, which were characterized by 1H NMR. Promastigotes, amastigotes and per...
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#1Keishi Yamasaki (Sojo University)H-Index: 24
#2Keiki Sakurama (Sojo University)H-Index: 3
Last. Kazuaki Taguchi (Sojo University)H-Index: 21
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OBJECTIVES Echinocandins are widely used for the treatment of invasive fungal diseases. While they bind strongly to plasma proteins, our knowledge of this process is not sufficient to permit their pharmacokinetics and pharmacodynamics targets to be discussed. In this study, we characterized the binding of two echinocandins, caspofungin and micafungin, to plasma proteins, human serum albumin (HSA) and human α 1-acid glycoprotein (AAG). METHODS The binding parameters, number of binding sites (n) a...
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#1Raquel Silva Araújo (UFMG: Universidade Federal de Minas Gerais)H-Index: 8
#2Mônica Cristina de Oliveira (UFMG: Universidade Federal de Minas Gerais)H-Index: 26
Last. Andrea M. Stringer (University of South Australia)H-Index: 29
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OBJECTIVES To circumvent cisplatin (CDDP) toxic effects and improve the antitumoural effect, our research group developed long-circulating and pH-sensitive liposomes containing CDDP (SpHL-CDDP). This study aimed to evaluate whether SpHL-CDDP is associated with intestinal protection under in-vitro conditions in the presence of host-microbiota, compared with free CDDP. METHODS The cytotoxicity of CDDP and SpHL-CDDP were evaluated by colorimetric MTT and sulforhodamine B (SRB) assays. Epithelial pr...
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#1Rui Huang (CQMU: Chongqing Medical University)
#2Zizuo Zhao (CQMU: Chongqing Medical University)
Last. Hong-Tao Tie (CQMU: Chongqing Medical University)H-Index: 14
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OBJECTIVES The chrysin has properties of low aqueous solubility, bioavailability and absorption, and its effect on hepatic ischaemia-reperfusion (HIR) remains unclear. Thus, we prepared a liposomal chrysin (LC) and explored its effect and potential mechanism on HIR. METHODS A thin-film dispersion method was used to prepare LC, and a mouse HIR model was used. Mice were pre-treated with LC (100 mg/kg) or placebo by gavage feeding at 16.5 h, 8.5 h, 0.5 h before modelling. RESULTS The average partic...
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#1Xinquan Li (AHUTCM: Anhui University of Traditional Chinese Medicine)H-Index: 2
#2Ya-Xun Cheng (AHUTCM: Anhui University of Traditional Chinese Medicine)
Last. Biao Cai (AHUTCM: Anhui University of Traditional Chinese Medicine)H-Index: 5
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OBJECTIVES Chrysophanol (CHR), also well-known as Rhei radix et rhizome, is a crucial component in traditional Chinese medicine. It has been widely studied as a potential treatment for many diseases due to its anti-inflammatory effects. However, there are very few studies to establish the potential therapeutic effect of CHR in cell and animal models of Alzheimer's disease (AD). Therefore, we aim to investigate whether CHR could be used as a potential therapeutic approach to patients with AD and ...
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