Journal of Pharmacy and Pharmacology
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#1Michael Heinrich (UCL: University College London)H-Index: 104
#2Haiping Jiang (UCL: University College London)
Last. Caroline Maake (UZH: University of Zurich)H-Index: 22
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BACKGROUND AND OBJECTIVES Adequate treatment of wounds remains one of the major medical needs globally, most notably in the regions with poor or limited access to health care. In many local and traditional systems of medicine, plants are often widely used for treating infected wounds. AIM AND OBJECTIVES The overarching aim of this project was selection of potential species for use in a future treatment by combining with plant resources with aspects of antimicrobial photodynamic therapy (aPDT). S...
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#1Izolene Corrêa Veloso (UFSC: Universidade Federal de Santa Catarina)
#2Eslen Delanogare (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
Last. Eduardo Luiz Gasnhar Moreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 18
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OBJECTIVE While chronic feeding with high-fat or high-sugar diets is known related to obesity and type 2 diabetes, later data have indicated that it is also related to depression and anxiety appearance. In this regard, multi-target drugs raise considerable interest as promising therapeutic solutions to complex diseases. Considering the pharmacological effects of the imidazopyridine-derivative moiety imidazo[1,2-a]pyridine and the organoselenium molecules, the combination of both could be a feasi...
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#1Bahareh Sadat Yousefsani (IUMS: Iran University of Medical Sciences)H-Index: 6
#2Motahareh Boozari (MUMS: Mashhad University of Medical Sciences)H-Index: 3
Last. Majid Dadmehr (IUMS: Iran University of Medical Sciences)H-Index: 8
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OBJECTIVES Iris germanica L. is a medicinal plant, which has a long history of uses, mainly in medieval Persia and many places worldwide for the management of a wide variety of diseases. In this study, we aimed to review ethnopharmacological applications in addition to phytochemical and pharmacological properties of I. germanica. KEY FINDINGS Ethnomedical uses of I. germanica have been reported from many countries such as China, Pakistan, India, Iran and Turkey. The medicinal part of I. germanic...
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OBJECTIVES This project aimed at the formulation of dual drug entrapped liposomes held as freeze-dried intravaginal rod insert (IVR), to be administered by vaginal route for uterine targeting. METHODS Liposomes were formulated by dehydration-rehydration method using 3 : 1 molar ratio of1,2-distearoyl-sn-glycero-3-phosphocholine : Cholesterol. Characterization was done for vesicle size, zeta potential, entrapment efficiency, surface morphology and % loading. KEY FINDINGS Spherical and discrete ve...
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#1Sarah S El-Sayed (Cairo University)
#2Mohammed F. El-Yamany (Cairo University)H-Index: 4
Last. Ayman E. El-Sahar (Cairo University)H-Index: 6
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OBJECTIVES As one of the most frequent worldwide neurological disorders, epilepsy is an alteration of the central nervous system (CNS) characterized by abnormal increases in neuronal electrical activity. The mammalian target of rapamycin (mTOR) signalling pathway has been investigated as an interesting objective in epilepsy research. Vinpocetine (VNP), a synthesized derivative of the apovincamine alkaloid, has been used in different cerebrovascular disorders. This study aimed to examine the modu...
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#1Muhammed Ossama (British University in Egypt)H-Index: 1
#2Rania M. Hathout (Ain Shams University)H-Index: 24
Last. Nahed D. Mortada (Ain Shams University)H-Index: 23
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OBJECTIVES The aim of this work was to study the effect of the physically adsorbed Poloxamer 188 coating polymer on the cytotoxic activity of allicin-loaded gelatin nanoparticles. METHODS The double desolvation method was utilised to prepare the nanoparticles which were characterised for particle size (PS), polydispersity index (PDI) and zeta potential and visualised using transmission electron microscopy. The coating density of the used polymer was determined using 1H-nuclear magnetic resonance...
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#1Zeynep Mine CoskunH-Index: 7
#2Alisa Bahar Beydogan (Istanbul University)H-Index: 1
Last. Sema Bolkent (Istanbul University)H-Index: 10
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OBJECTIVES This study was designed to clarify the effects of ghrelin on myocardial and aortic tissues in insulin-resistant rats. METHODS Sprague-Dawley rats were divided into the following groups: control (Group 1), insulin resistance (IR, Group 2), ghrelin (Group 3) and IR+Ghrelin (Group 4) groups. Levels of HOMA-IR, fibronectin, hydroxyproline, collagen-1, collagen-3, matrix metalloproteinase-3, and matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1, and oxidative stress p...
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OBJECTIVES Ovarian cancer is a lethal gynecological malignancy. Long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) was reported to have a critical role in cancer advancement. The ANRIL-mediated oncogenic underlying molecular mechanisms are not fully understood in ovarian cancer. We aimed to study ANRIL silencing effects on the proliferation and apoptosis of OVCAR-3 cells. METHODS The ANRIL was Knockdown by transfection of OVCAR-3 cells with si-RNA against ANRIL. MTT as...
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#1Dima W. Alhamad (UOS: University of Sharjah)H-Index: 2
#2Sara M. Elgendy (UOS: University of Sharjah)H-Index: 2
Last. Hany A. Omar (UOS: University of Sharjah)H-Index: 22
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OBJECTIVES Cancer is a leading cause of disabling morbidities and death worldwide. Although there are various strategies for the management of cancer, the severe adverse effects negatively impact the patient's quality of life. In addition, the development of resistance limits the efficacy of many chemotherapeutics. Many natural agents are capable of reducing the adverse effects associated with chemotherapy and improving the therapeutic outcome. Tangeretin, a polymethoxy flavone, is one of the pr...
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OBJECTIVES This study investigated the prolonged diuretic and renal effects of 1,3,5,6- tetrahydroxyxanthone (THX) in rats. METHODS Normotensive (NTR) and hypertensive rats (SHR) received orally the treatment with THX, hydrochlorothiazide or vehicle (VEH). Urine volume, urinary, plasma and kidney parameters were evaluated daily or at the end of 7 days of the experiment. KEY FINDINGS The urinary volume of both NTR and SHR were significantly augmented with the THX treatment, an effect associated w...
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