Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma

Published on May 13, 2013in Investigative Ophthalmology & Visual Science4.799
· DOI :10.1167/IOVS.13-11676
Renato Lisboa13
Estimated H-index: 13
(UCSD: University of California, San Diego),
Augusto Paranhos17
Estimated H-index: 17
(UNIFESP: Federal University of São Paulo)
+ 3 AuthorsFelipe A. Medeiros84
Estimated H-index: 84
(UCSD: University of California, San Diego)
Sources
Abstract
RESULTS. The three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 6 0.03), inferior hemisphere average thickness (0.87 6 0.03), and inferior quadrant average thickness (0.85 6 0.03). The three ONH parameters with the largest AUCs were vertical cupto-disc ratio (0.74 6 0.04), rim area (0.72 6 0.05), and rim volume (0.72 6 0.05). The three macular parameters with the largest AUCs were GCC average thickness (0.79 6 0.04), GCC inferior thickness (0.79 6 0.05), and GCC superior thickness (0.76 6 0.05). Average RNFL thickness performed better than vertical cup-to-disc ratio (0.89 vs. 0.74; P ¼ 0.007) and GCC average thickness (0.89 vs. 0.79; P ¼ 0.015). CONCLUSIONS. SDOCT RNFL measurements performed better than ONH and macular measurements for detecting preperimetric glaucomatous damage in a cohort of glaucoma suspects. (ClinicalTrials.gov number, NCT00221897.)
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Purpose To evaluate the diagnostic accuracy of spectral domain optical coherence tomography (SD-OCT) for detection of preperimetric glaucoma and compare it with the performance of confocal scanning laser ophthalmoscopy (CSLO). Design Cohort study. Participants A cohort of 134 eyes of 88 glaucoma suspects based on the appearance of the optic disc. Methods Patients were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS). All eyes underwent retinal nerve fiber layer (RNFL) imaging w...
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#1Felipe A. Medeiros (UCSD: University of California, San Diego)H-Index: 84
#2Linda M. ZangwillH-Index: 96
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#1Christopher Kai-Shun Leung (CUHK: The Chinese University of Hong Kong)H-Index: 56
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